Author

K. Pfeffer

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 3 Biochemistry· 1 Biophysics· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Organism:mouse· 5 Research Focus:host-pathogen & immune response· 4 Organism:human· 2 Assay:proteomics· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Approach:deep learning· 1

Frequent Co-Authors

D. Degrandi· 5 shared B. Strodel· 2 shared G. Poschmann· 2 shared J. Loschwitz· 2 shared K. Stuehler· 2 shared A. Bozec· 1 shared A. F. Arenas Soto· 1 shared A. K. Tersteegen· 1 shared

Activity by Year

2021-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 15 mutual co-author links

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5 shared papersImmunology

D. Degrandi

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Dual role of Toxoplasma gondii ROP5 and ROP18 for NLRP3 inhibition

M. Murillo-Leon, A. M. Bastidas Quintero, S. Singh, X. Mueller, O. Gorka, B. Saller, A. F. Arenas Soto, C. Campos, J. E. Gomez-Marin, O. Gross, K. Pfeffer, J. C. Howard, G. A. Taylor, T. Steinfeldt

This paper identifies vacuolar disruption as a trigger for NLRP3 inflammasome activation in Toxoplasma gondii infection and shows ROP5 and ROP18 inhibit IL-1β release by protecting the parasitophorous vacuole and interacting with GBP5.

bioRxiv · Sep 17, 2023 · PreprintMicrobiology

Integrative modeling of guanylate binding protein dimers

W. Schumann, J. Loschwitz, J. Reiners, D. Degrandi, K. Pfeffer, K. Stuehler, G. Poschmann, S. Smits, B. Strodel

The paper models dimer structures of GBP proteins using integrative methods, revealing structural differences that explain functional divergence.

bioRxiv · Dec 20, 2022Biochemistry

Macrophages inhibit Coxiella burnetii by the ACOD1-itaconate pathway for containment of Q fever

L. Kohl, N. A. A. Siddique, B. Bodendorfer, R. Berger, A. Preikschat, C. Daniel, M. Oelke, M. Mauermeir, K.-T. Yang, I. Hayek, M. Szperlinski, J. Schulze-Luehrmann, U. Schleicher, A. Bozec, G. Kroenke, , R. Lang

This study identifies the ACOD1-itaconate pathway in macrophages as critical for restricting Coxiella burnetii replication and proposes it as a therapeutic target for Q fever.

bioRxiv · May 10, 2022Immunology

Domain motions, dimerization, and membrane interactions of the murine guanylate binding protein 2

J. Loschwitz, N. Steffens, X. Wang, M. Schaeffler, K. Pfeffer, D. Degrandi, B. Strodel

This study investigates the molecular mechanisms of murine GBP2, revealing its lipid-binding affinity and dynamic behavior on membranes, which may contribute to membrane destruction.

bioRxiv · Apr 27, 2022 · PreprintBiophysics

GBP2 engages Galectin-9 for immunity against Toxoplasma gondii

E. Kravets, G. Poschmann, S. Haensch, V. Raba, S. Weidtkamp-Peters, D. Degrandi, K. Stuehler, K. Pfeffer

This study identifies Galectin-9 as a critical interaction partner of mGBP2 required for immune control of Toxoplasma gondii.

bioRxiv · Dec 28, 2021 · PreprintImmunology

Lymphotoxin β receptor: A crucial role in innate and adaptive immune responses against Toxoplasma gondii

A. K. Tersteegen, U. R. Sorg, R. Virgen-Slane, M. Helle, P. Petzsch, I. R. Dunay, K. Köhrer, D. Degrandi, C. F. Ware, K. Pfeffer

This study shows that the Lymphotoxin β receptor is critical for immune responses against Toxoplasma gondii, affecting cytokine regulation and adaptive immunity.

bioRxiv · Jan 11, 2021Immunology