Author

K. R. Hughes

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 2

Signature Assays, Organisms & Methods

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Research Focus:host-pathogen & immune response· 2 Organism:mouse· 2 Approach:experimental assay· 1 Approach:genetic perturbation / CRISPR· 1 Assay:metagenomics· 1

Frequent Co-Authors

A. B. Roberts· 1 shared A. J. Watson· 1 shared A. P. Waters· 1 shared C. Alcon-Giner· 1 shared F. Bernuzzi· 1 shared G. Le Gall· 1 shared L. Chalklen· 1 shared L. J. Hall· 1 shared

Activity by Year

2019-2019 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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1 shared paperMicrobiology

A. B. Roberts

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2 papers

Recent·Most cited

MicrobiologybioRxivDec 12, 2019

Experimentally engineered mutations in a ubiquitin hydrolase, UBP-1, modulate in vivo resistance to artemisinin and chloroquine in Plasmodium berghei.

N. V. Simwela, K. R. Hughes, A. B. Roberts…·A. P. Waters

This study experimentally tests mutations in UBP-1 in Plasmodium berghei and shows they confer resistance to artemisinin and chloroquine.

DOI 10.1128/aac.02484-19

mousegenetic perturbation / CRISPR

𝕏 PostBluesky

MicrobiologybioRxivOct 2, 2019

The early life microbiota protects neonatal mice from pathological small intestinal epithelial cell shedding

K. R. Hughes, Z. Schofield, M. J. Dalby…·L. J. Hall

This study shows that early life gut microbiota in mice prevents pathological small intestinal epithelial cell shedding, with antibiotic treatment reversing this protection.

DOI 10.1096/fj.202000042r

mousemetagenomics

𝕏 PostBluesky