N. V. Simwela

This paper identifies a conserved metabolic signature in malaria parasites exposed to fast-acting antimalarial drugs, suggesting a common mechanism of action.

This study introduces K13 mutations into Plasmodium berghei to demonstrate their role in mediating artemisinin resistance in vivo, showing delayed parasite clearance and synergistic effects with proteasome inhibitors.

This paper shows that mammalian deubiquitinating enzyme inhibitors inhibit malaria parasites in vitro and in vivo, and enhance artemisinin activity, offering a strategy to combat artemisinin resistance.

This study experimentally tests mutations in UBP-1 in Plasmodium berghei and shows they confer resistance to artemisinin and chloroquine.