Author

K. Rantalainen

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 4 Biochemistry· 1

Signature Assays, Organisms & Methods

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Assay:proteomics· 4 Research Focus:cell type annotation· 3 Approach:experimental assay· 3 Research Focus:host-pathogen & immune response· 3 Organism:human· 2 Assay:structural biology· 2 Research Focus:cell-cell communication· 1 Research Focus:clustering· 1

Frequent Co-Authors

A. Antanasijevic· 4 shared M. Crispin· 4 shared A. Ward· 3 shared J. Copps· 3 shared J. D. Allen· 3 shared R. W. Sanders· 3 shared A. B. Ward· 2 shared A. Torrents de la Pena· 2 shared

Activity by Year

2018-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

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4 shared papersImmunology

A. Antanasijevic

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Glycan heterogeneity as a cause of the persistent fraction in HIV-1 neutralization

R. P. Ringe, P. Colin, G. Ozorowski, J. Allen, A. Yasmeen, G. Seabright, J. H. Lee, A. Antanasijevic, K. Rantalainen, T. Ketas, J. Moore, A. Ward, M. Crispin, P. J. Klasse

This study investigates how glycan heterogeneity on HIV-1 Env contributes to persistent infectivity despite neutralizing antibody (NAb) treatment, showing that glycan variants affect antibody binding and neutralization efficacy.

bioRxiv · Aug 8, 2023Immunology

Polyclonal antibody responses to HIV Env immunogens resolved using cryoEM

A. Antanasijevic, L. M. Sewall, C. A. Cottrell, D. G. Carnathan, L. E. Jimenez, J. T. Ngo, J. B. Silverman, B. Groschel, E. Georgeson, J. Bhiman, R. Bastidas, C. LaBranche, J. D. Allen, J. Copps, H. R. Perrett, , A. B. Ward

The paper uses cryoEM to analyze polyclonal antibody responses to HIV Env immunogens in rhesus macaques, revealing structural differences in antibody binding and immunogenicity of engineered mutations and glycan sites.

bioRxiv · Jan 28, 2021Immunology

Enhancing glycan occupancy of soluble HIV-1 envelope trimers to mimic the native viral spike

R. Derking, J. D. Allen, C. Cottrell, K. Sliepen, G. E. Seabright, W.-H. Lee, K. Rantalainen, A. Antanasijevic, J. Copps, A. Yasmeen, P. van der Woude, S. W. de Taeye, T. L. G. M. van den Kerkhof, P. J. Klasse, G. Ozorowski, , R. W. Sanders

The paper modifies HIV-1 Env trimers to increase glycan occupancy and reduce artificial glycan holes, improving vaccine antigen design.

bioRxiv · Jul 2, 2020Biochemistry

HIV-1 Envelope and MPER antibody structures in lipid assemblies

K. Rantalainen, Z. T. Berndsen, A. Antanasijevic, T. Schiffner, X. Zhang, W.-H. Lee, J. L. Torres, L. Zhang, A. Irimia, J. Copps, K. Zhou, Y. D. Kwon, W. H. Law, C. A. Schramm, R. Verardi, , A. Ward

This study presents methods to incorporate full-length HIV-1 Env into lipid assemblies for structural analysis, revealing the quaternary epitope of an MPER antibody and Env tilting during neutralization.

bioRxiv · Nov 15, 2019Immunology

Similarities and differences between native HIV-1 envelope glycoprotein trimers and stabilized soluble trimer mimetics

A. Torrents de la Pena, K. Rantalainen, C. A. Cottrell, J. D. Allen, M. J. van Gils, J. L. Torres, M. Crispin, R. W. Sanders, A. B. Ward

This study compares native HIV-1 Env trimers with soluble SOSIP trimers, finding structural and antigenic similarities but differences in antibody binding and glycan composition.

bioRxiv · Dec 20, 2018Immunology