Author

C. Cottrell

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 3 Biochemistry· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:host-pathogen & immune response· 3 Research Focus:cell type annotation· 2 Approach:deep learning· 1 Research Focus:drug response / drug discovery· 1 Approach:genetic perturbation / CRISPR· 1 Organism:human· 1 Assay:imaging· 1

Frequent Co-Authors

A. B. Ward· 2 shared D. Burton· 2 shared D. Nemazee· 2 shared D. Sok· 2 shared G. Ozorowski· 2 shared H. L. Turner· 2 shared I. A. Wilson· 2 shared M. J. van Gils· 2 shared

Activity by Year

2019-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 34 mutual co-author links

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2 shared papersImmunology

A. B. Ward

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Efficient isolation of rare B cells using next-generation antigen barcoding

J. Hurtado, C. Flynn, J. H. Lee, E. Salcedo, C. Cottrell, P. D. Skog, D. Nemazee, W. R. Schief, E. Landais, D. Sok, B. Briney

This paper introduces a method for efficiently isolating rare antigen-specific B cells using next-generation antigen barcoding and a computational framework, demonstrating its ability to recover thousands of mAbs, including rare HIV broadly neutralizing antibodies.

bioRxiv · Jun 6, 2022Immunology

A broad and potent neutralization epitope in SARS-related coronaviruses

M. Yuan, X. Zhu, W.-t. He, P. Zhou, C. I. Kaku, T. Capozzola, C. Y. Zhu, X. Yu, H. Liu, W. Yu, Y. Hua, H. Tien, L. Peng, G. Song, C. Cottrell, , I. A. Wilson

The paper identifies a broadly neutralizing epitope in SARS-related coronaviruses that is effective against variants, including Omicron, and suggests its use for universal vaccine design.

bioRxiv · Mar 13, 2022 · PreprintMicrobiology

Enhancing glycan occupancy of soluble HIV-1 envelope trimers to mimic the native viral spike

R. Derking, J. D. Allen, C. Cottrell, K. Sliepen, G. E. Seabright, W.-H. Lee, K. Rantalainen, A. Antanasijevic, J. Copps, A. Yasmeen, P. van der Woude, S. W. de Taeye, T. L. G. M. van den Kerkhof, P. J. Klasse, G. Ozorowski, , R. W. Sanders

The paper modifies HIV-1 Env trimers to increase glycan occupancy and reduce artificial glycan holes, improving vaccine antigen design.

bioRxiv · Jul 2, 2020Biochemistry

Mapping polyclonal antibody responses in non-human primates vaccinated with HIV Env trimer subunit vaccines

B. Nogal, M. Bianchi, C. Cottrell, R. N. Kirchdoerfer, L. M. Sewall, H. L. Turner, F. Zhao, D. Sok, D. Burton, L. Hangartner, A. B. Ward

This study maps polyclonal antibody responses in non-human primates vaccinated with HIV Env trimer subunit vaccines and identifies epitopes associated with neutralization breadth.

bioRxiv · Nov 7, 2019Immunology

Neutralizing antibody responses to an HIV envelope glycan hole are not easily broadened

Y. R. Yang, L. E. McCoy, M. J. van Gils, R. Andrabi, H. L. Turner, M. Yuan, C. Cottrell, G. Ozorowski, J. E. Voss, M. Pauthner, T. M. Polveroni, T. Messmer, I. A. Wilson, R. W. Sanders, D. R. Burton, A. B. Ward

This study shows that immunization with B41 and BG505 SOSIP trimer immunogens in rabbits induces distinct autologous neutralizing antibody lineages targeting overlapping glycan hole epitopes, but broadening reactivity remains challenging.

bioRxiv · Nov 1, 2019Immunology