S. Mori

Intraoperative Ablation Control Based on Real-time Necrosis Monitoring Feedback: Numerical Evaluation

This paper evaluates NFB control for ablation therapy, showing it provides more accurate control than TFB when NF model errors are present.

The minimal SUF system can substitute for the canonical iron-sulfur cluster biosynthesis systems by using inorganic sulfide as the sulfur source.

FGF9, a potent mitogen, is a new ligand for integrin αvβ3, and the FGF9 mutant defective in integrin binding acts as an antagonist.

This study identifies FGF9 as a new ligand for integrin αvβ3 and shows that a mutant defective in integrin binding acts as an antagonist by suppressing FGF9 signaling.

Precise immunofluorescence canceling for highly multiplexed imaging capturing specific cell state

The paper introduces PECAbs for high-specificity multiplexed imaging of cell states and combines them with seq-smFISH to classify cells and identify signal activation states in human tissue.

Screening for novel RyR2 inhibitors by ER Ca2+ monitoring

This study identifies three RyR2 inhibitors using an ER Ca2+ monitoring assay, showing they suppress arrhythmogenic Ca2+ waves without affecting normal Ca2+ transients.

Cell polarity linked to gravity sensing is generated by protein translocation from statoliths to the plasma membrane.

This study identifies LAZY1-LIKE proteins as gravity sensors in plant statocytes, showing their polar localization based on gravity direction.

Cotranscriptional demethylation induces global loss of H3K4me2 from active genes in Arabidopsis

This study shows that LDL3-mediated H3K4me2 demethylation occurs cotranscriptionally in Arabidopsis, disrupting the negative correlation between H3K4me2 and transcription in the ldl3 mutant.

Characterization of HcaA, a novel autotransporter protein in Helicobacter cinaedi, and its role in host cell adhesion

This study identifies HcaA, a novel autotransporter protein in H. cinaedi, as critical for host cell adhesion and bacterial colonization through its RGD motif.

Reconstituted depolarization-induced Ca2+ release platform for skeletal muscle disease mutation validation and drug discovery

The paper establishes a reconstituted DICR platform in HEK293 cells to validate skeletal muscle disease mutations and test drug candidates.

Amygdalar and ERC Rostral Atrophy and Tau Pathology Reconstruction in Preclinical Alzheimer's Disease

This study measures amygdala and ERC atrophy rates in preclinical Alzheimer's disease using MRI and reconstructs 3D tau pathology distributions, finding amygdala atrophy comparable to ERC and suggesting it as a potential biomarker.

MRSCloud: a Cloud-based MR Spectroscopy Tool for Basis Set Simulation

MRSCloud is a cloud-based tool for simulating MR spectroscopy basis sets, achieving high accuracy and reduced runtime compared to existing methods.

Projective LDDMM: Spatially Reconstructing a Story of Rostrally-Dominant Tau in Alzheimer's Disease

The paper aligns 2D histology images of AD pathology with 3D MRI to reconstruct NFT density in the MTL, finding high NFT density in the rostral hippocampus and adjacent regions.

Identification, crystallization and epitope determination of public TCR shared and expanded in COVID-19 patients

The paper identifies and crystallizes public TCRs from SARS-CoV-2-specific Tfh cells in COVID-19 patients, showing they recognize conserved spike epitopes and cross-react with symbiotic bacteria.

A novel RyR1 inhibitor prevents and rescues sudden death in a mouse model of malignant hyperthermia and heat stroke

This study introduces a novel RyR1 inhibitor that prevents and rescues MH and heat stroke in mouse models, offering improved solubility and clearance compared to dantrolene.

\"Low-cost\" initial burst of root development in whole Fagus crenata seedlings: The key to survival?

The paper measures metabolic rates and growth in Fagus crenata seedlings to show roots develop more rapidly and efficiently than other organs, supporting seedling survival.

The effect of anti-IL-6 receptor antibody for the treatment of McH-lpr/lpr-RA1 mice that spontaneously developed ankylosing arthritis

This study evaluates the effectiveness of an anti-IL-6 receptor antibody in reducing synovitis and bone destruction in McH-lpr/lpr-RA1 mice with ankylosing arthritis, showing partial success in inflammation but not in preventing ankylosis progression.