Author

E. Xu

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioengineering· 4 Biochemistry· 1 Cell Biology· 1 Synthetic Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Research Focus:cell type annotation· 4 Organism:human· 4 Research Focus:differential expression· 3 Assay:imaging· 3 Organism:mouse· 2 Assay:proteomics· 2 Research Focus:spatial domain detection· 2

Frequent Co-Authors

C. Chen· 2 shared D. J. Tward· 2 shared J. Troncoso· 2 shared K. Stouffer· 2 shared M. Albert· 2 shared M. Witter· 2 shared S. Mori· 2 shared A. B. West· 1 shared

Activity by Year

2018-2024 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 22 mutual co-author links

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2 shared papersBioengineering

C. Chen

Mutual co-authors in cluster

Author profile →

7 papers

Recent·Most cited

Synergistic Multi-Enzyme Cascades Assembled on Modular Protein Scaffolds for Efficient PET Biorecycling

Y. Zhang, C. Li, E. Hashemi, E. Xu, X. Yang, Y. Lin, H. Gao, Z. Liang

This paper develops a modular protein scaffold system to assemble multiple enzymes for efficient PET biorecycling, achieving higher conversion rates than previous systems.

bioRxiv · Sep 16, 2024 · PreprintSynthetic Biology

A compact breast shape acquisition system for improving diffuse optical tomography image reconstructions

M. Vanegas, M. M. Nunez, E. Xu, S. Yan, Q. Fang

This paper develops a compact breast shape acquisition system that improves diffuse optical tomography image reconstructions by reducing surface estimation errors and increasing absorption coefficient accuracy.

bioRxiv · Nov 20, 2022Bioengineering

Amygdalar and ERC Rostral Atrophy and Tau Pathology Reconstruction in Preclinical Alzheimer's Disease

K. Stouffer, C. Chen, S. Kulason, E. Xu, M. Witter, C. Ceritoglu, M. Albert, S. Mori, J. Troncoso, D. J. Tward, M. I. Miller

This study measures amygdala and ERC atrophy rates in preclinical Alzheimer's disease using MRI and reconstructs 3D tau pathology distributions, finding amygdala atrophy comparable to ERC and suggesting it as a potential biomarker.

bioRxiv · Jun 6, 2022 · PreprintBioengineering

Projective LDDMM: Spatially Reconstructing a Story of Rostrally-Dominant Tau in Alzheimer's Disease

K. Stouffer, M. Witter, C. Chen, E. Xu, M. Albert, S. Mori, J. Troncoso, D. J. Tward, M. Miller

The paper aligns 2D histology images of AD pathology with 3D MRI to reconstruct NFT density in the MTL, finding high NFT density in the rostral hippocampus and adjacent regions.

bioRxiv · Mar 16, 2022 · PreprintBioengineering

In vivo correction of cystic fibrosis mediated by PNA nanoparticles

A. S. Piotrowski-Daspit, C. Barone, C.-Y. Lin, Y. Deng, D. Wu, T. C. Binns, E. Xu, A. S. Ricciardi, R. Putman, R. Nguyen, A. Gupta, R. Fan, P. Glazer, W. M. Saltzman, M. E. Egan

This study demonstrates systemic gene editing using PNA nanoparticles to correct the F508del CFTR mutation in mice, showing partial CFTR function restoration and tissue-specific correction without off-target effects.

bioRxiv · Jan 28, 2022Bioengineering

LRRK2 and Rab10 Coordinate Macropinocytosis to Mediate Immunological Responses in Phagocytes

Z. Liu, E. Xu, H. Zhao, T. Cole, A. B. West

This study shows LRRK2 and Rab10 coordinate macropinocytosis in phagocytes, with LRRK2 phosphorylating Rab10 to block cargo recycling and promote signaling endosome maturation.

bioRxiv · Jan 30, 2020Cell Biology

Mammalian stringent-like response mediated by the cytosolic NADPH phosphatase MESH1

C.-K. C. Ding, J. Rose, J. Wu, T. Sun, K.-Y. Chen, P.-H. Chen, E. Xu, S. Tian, J. Akinwuntan, Z. Guan, P. Zhou, J.-T. A. Chi

This study identifies MESH1 as a cytosolic NADPH phosphatase that promotes cell survival under ferroptosis by maintaining NADPH levels and induces transcriptional changes resembling bacterial stringent response.

bioRxiv · May 17, 2018Biochemistry