Author

K. Strange

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 1 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell signaling & trafficking· 2 Approach:experimental assay· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:chromatin & epigenetic regulation· 1 Assay:metabolomics· 1 Organism:mouse· 1 Research Focus:protein structure prediction· 1 Assay:proteomics· 1

Frequent Co-Authors

A. Guo· 1 shared A. J. Ovens· 1 shared A. M. Carter· 1 shared A. Natarajan· 1 shared A. Sobh· 1 shared C. Tan· 1 shared E. Karakas· 1 shared H. Hatch· 1 shared

Activity by Year

2022-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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1 shared paperCancer Biology

A. Guo

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2 papers

Recent·Most cited

Structure of a LRRC8 chimera with physiologically relevant properties reveals heptameric assembly and pore-blocking lipids

H. Takahashi, T. Yamada, J. S. Denton, K. Strange, E. Karakas

The paper describes a LRRC8 chimera with physiologically relevant properties, revealing a heptameric structure and the role of membrane lipids in channel function.

bioRxiv · Jul 28, 2022Biophysics

Genetic Impairment of Succinate Metabolism Disrupts Bioenergetic Sensing in Adrenal Neuroendocrine Cancer

P. Gupta, K. Strange, R. Telange, A. Guo, H. Hatch, A. Sobh, J. Elie, A. M. Carter, J. Totenhagen, C. Tan, Y. A. Sonawane, J. Neuzil, A. Natarajan, A. J. Ovens, J. S. Oakhill, , J. A. Bibb

This paper shows that loss of SDHB in adrenal neuroendocrine cancer disrupts bioenergetic sensing through Cdk5 activation, leading to tumor progression, and that Cdk5 inhibition can reverse this process.

bioRxiv · Jan 9, 2022Cancer Biology