A. Natarajan

Novel spirocyclic dimer, SpiD3, targets chronic lymphocytic leukemia survival pathways with potent preclinical effects

This paper evaluates SpiD3, a novel spirocyclic dimer, showing potent anti-leukemic effects in CLL cells, including resistance to ibrutinib, by targeting NF-κB signaling and the UPR.

Profiling cell envelope-antibiotic interactions reveals vulnerabilities to β-lactams in a multidrug-resistant bacterium

This study identifies cell envelope-associated resistance and susceptibility determinants in Burkholderia cenocepacia using transposon mutagenesis and antibiotic profiling, revealing new vulnerabilities to β-lactams and the mechanism of cefiderocol.

Design, synthesis, and evaluation of a mitoxantrone probe (MXP) for biological studies

The paper describes the design and synthesis of a mitoxantrone-biotin probe (MXP) to identify and characterize cellular targets of mitoxantrone, demonstrating its ability to isolate RAD52.

DHODH inhibition enhances the efficacy of immune checkpoint blockade by increasing cancer cell antigen presentation

This study shows DHODH inhibition enhances immune checkpoint blockade by increasing cancer cell antigen presentation through pyrimidine depletion and P-TEFb-mediated RNA polymerase II elongation.

GD2 and its biosynthetic enzyme GD3 synthase promote tumorigenesis in prostate cancer by regulating cancer stem cell behavior

This study shows GD2 and its biosynthetic enzyme GD3S promote prostate cancer tumorigenesis by maintaining cancer stem cells and EMT markers.

Tomato brown rugose fruit virus Mo gene is a novel microbial source tracking marker

The paper designs and tests novel viral microbial source tracking markers based on ToBRFV genomes, finding they are sensitive, specific, and more prevalent in human stool and wastewater than existing markers.

Heart Rate Variability During Mindful Breathing Meditation

The paper analyzes HRV during mindful breathing meditation, introduces a new metric ABI, and shows it is elevated during meditation.

Cooperative cis-interactions between ectodomains of TCRαβ CD3 subunits enable mechanotransduction

The paper quantifies cooperative cis-interactions between TCRβ and CD3 subunits, showing they form catch bonds that mechanically regulate TCR signaling.

In situ cell-surface conformation of the TCR-CD3 signaling complex

The paper uses photo-crosslinking and computational docking to determine the in situ cell-surface conformation of the TCR-CD3 complex, revealing a novel arrangement of CD3 subunits around the TCR.

Catch bond models may explain how force amplifies TCR signaling and antigen discrimination

The paper develops models to explain how force affects TCR signaling and antigen discrimination by analyzing bond characteristics of TCR-pMHC interactions.

Genetic Impairment of Succinate Metabolism Disrupts Bioenergetic Sensing in Adrenal Neuroendocrine Cancer

This paper shows that loss of SDHB in adrenal neuroendocrine cancer disrupts bioenergetic sensing through Cdk5 activation, leading to tumor progression, and that Cdk5 inhibition can reverse this process.

Fbxo7 promotes Cdk6 activity to inhibit PFKP and glycolysis in T cells.

This study identifies Fbxo7's role in promoting Cdk6 activity to inhibit PFKP and glycolysis in T cells, revealing its impact on metabolism and viability.

Heart Rate Variability with Photoplethysmography in 8 Million Individuals: Results and Scaling Relations with Age, Gender, and Time of Day

The paper analyzes heart rate variability in 8 million individuals using photoplethysmography, finding scaling relations with age, gender, and time of day, and a correlation between daily steps and optimal heart rate variability.