A. Guo

Shrimp Hemocyanin elicits a potent humoral response in mammals and is favorable to hapten conjugation

This study shows shrimp hemocyanin (SHC) can replace keyhole limpet hemocyanin (KLH) as a carrier protein for hapten conjugation, offering better solubility and comparable immunogenicity in mammals.

Structure-conditioned masked language models for protein sequence design generalize beyond the native sequence space

This paper introduces Frame2seq, a structure-conditioned masked language model for protein sequence design that generates novel, stable proteins with low sequence identity to native sequences.

A Plant Flavonol Rescues a Pathogenic Mutation Associated with Kinesin in Neurons

The paper identifies fisetin, a plant flavonol, as a potential therapeutic for KIF1A(R11Q)-associated neurological disorder by restoring ATPase activity and movement of the mutant protein.

Tracking the Metabolic Fate of Exogenous Arachidonic Acid in Ferroptosis Using Dual-Isotope Labeling Lipidomics

This paper develops a dual-isotope labeling method to track exogenous arachidonic acid metabolism in ferroptosis using HILIC-IM-MS and a Python-based software tool.

TPR domain assigns versatility of BcTir/Tpr system against viral infection

The paper identifies the BcTir/Tpr system in Bacillus cereus as a defense mechanism against phage infection, showing BcTpr's dual role in NAD+ depletion and cADPR isomer production.

Genetic Impairment of Succinate Metabolism Disrupts Bioenergetic Sensing in Adrenal Neuroendocrine Cancer

This paper shows that loss of SDHB in adrenal neuroendocrine cancer disrupts bioenergetic sensing through Cdk5 activation, leading to tumor progression, and that Cdk5 inhibition can reverse this process.

Small RNA profiling in Mycobacterium insights into stress adapt ability

The paper identifies stress-responsive small RNAs in Mycobacteria, finding some are linked to lipid metabolism and virulence.

Sequence Determinants of Human Junctophilin-2 Protein Nuclear Localization and Phase Separation

This study identifies nuclear localization signals and phase separation properties of human JPH2, revealing its ability to form liquid droplets and amyloid-like aggregates in the nucleus.

Automation of Leaf Counting in Maize and Sorghum Using Deep Learning

This paper develops and evaluates deep learning models for automated leaf counting in maize and sorghum, achieving performance close to human annotators.

Reciprocal regulation of vacuolar calcium transport and V-ATPase activity, and the effects of Phosphatidylinositol 3,5-bisphosphate

This study shows that Ca2+ and H+ transport across the yeast vacuole membrane are reciprocally regulated and linked to Phosphatidylinositol 3,5-bisphosphate production.

Phosphoprotein-based Biomarkers as Predictors for Cancer Therapy

The paper identifies phosphoprotein biomarkers for Cdk5 activity in neuroendocrine tumors and shows their predictive value for anti-Cdk5 therapy.

Copper Blocks V-ATPase Activity and SNARE Complex Formation to Inhibit Yeast Vacuole Fusion

This study shows that copper inhibits yeast vacuole fusion by blocking SNARE complex formation and V-ATPase activity, with Cu2+ being the active species.

Phosphatidylinositol 3,5-Bisphosphate regulates Ca2+ Transport During Yeast Vacuolar Fusion through Activation of the Ca2+ ATPase Pmc1

This study shows that PI(3,5)P2 regulates Ca2+ transport in yeast vacuoles by activating Pmc1 during fusion, opposing its role in fission.

Phosphatidylinositol 3,5-Bisphosphate Regulates Yeast Vacuole Fusion at the Transition between trans-SNARE Complex Formation and Hemifusion

This study shows that PI(3,5)P2 inhibits yeast vacuole fusion after SNARE complex formation and during hemifusion, acting as a molecular switch between fission and fusion.