Author

E. Karakas

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 7 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Organism:human· 5 Research Focus:protein structure prediction· 5 Assay:cryo-EM· 4 Research Focus:cell signaling & trafficking· 2 Approach:microscopy & imaging analysis· 2 Research Focus:protein folding & dynamics· 2 Research Focus:cell type annotation· 1

Frequent Co-Authors

A. K. Kenworthy· 4 shared B. Han· 4 shared M. D. Ohi· 4 shared A. Gulsevin· 3 shared H. Mchaourab· 3 shared J. Meiler· 3 shared S. Connolly· 3 shared Y. Peskova· 3 shared

Activity by Year

2020-2023 · peak 5/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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4 shared papersBiophysics

A. K. Kenworthy

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8 papers

Recent·Most cited

Asymmetric conformations and lipid interactions shape the ATP-coupled cycle of a heterodimeric ABC transporter

Q. Tang, M. Sinclair, H. S. Hasdemir, R. A. Stein, E. Karakas, E. Tajkhorshid, H. Mchaourab

This study uses cryo-EM, DEER, and MD simulations to analyze the conformational dynamics of BmrCD, revealing asymmetric ATP and substrate interactions that drive its transport cycle.

bioRxiv · May 29, 2023Biophysics

Evolutionarily diverse caveolins share a common structural framework built around amphipathic discs

B. Han, S. Connolly, L. F. L. Wilson, D. T. Schultz, A. Gulsevin, J. Meiler, E. Karakas, M. D. Ohi, A. K. Kenworthy

The paper predicts structures for 73 caveolins across animal diversity and identifies conserved structural elements and amphipathic disc assembly, revealing an ancient structural framework predating Metazoa.

bioRxiv · Nov 15, 2022Biophysics

Structure of a LRRC8 chimera with physiologically relevant properties reveals heptameric assembly and pore-blocking lipids

H. Takahashi, T. Yamada, J. S. Denton, K. Strange, E. Karakas

The paper describes a LRRC8 chimera with physiologically relevant properties, revealing a heptameric structure and the role of membrane lipids in channel function.

bioRxiv · Jul 28, 2022Biophysics

Structural characterization of a breast cancer-associated mutation in caveolin-1

B. Han, A. Gulsevin, S. Connolly, T. Wang, J. Porta, A. Tiwari, A. Deng, L. Chang, Y. Peskova, H. Mchaourab, E. Karakas, M. D. Ohi, J. Meiler, A. K. Kenworthy

This study examines how a breast cancer-associated mutation in CAV1, P132L, affects its structure and oligomerization, revealing its impact on caveolae formation.

bioRxiv · May 23, 2022 · PreprintBiophysics

Structural insights into the mechanism of the sodium/iodide symporter (NIS)

S. Ravera, J. P. Nicola, G. Salazar de Simone, F. J. Sigworth, E. Karakas, L. M. Amzel, M. A. Bianchet, N. Carrasco

This study reports three cryo-EM structures of rat NIS, revealing substrate binding sites and transport mechanisms, and provides insights into anion selection and translocation.

bioRxiv · Apr 7, 2022Biophysics

Molecular architecture of the human caveolin-1 complex

J. C. Porta, B. Han, A. Gulsevin, J. Chung, Y. Peskova, S. Connolly, H. Mchaourab, J. Meiler, E. Karakas, A. K. Kenworthy, M. D. Ohi

The paper uses cryo-electron microscopy to reveal the structure of the human caveolin-1 complex, showing it forms a disc with a flat membrane-binding surface.

bioRxiv · Feb 17, 2022Biophysics

Structural basis for activation and gating of IP3 receptors

E. A. Schmitz, H. Takahashi, E. Karakas

The paper reports cryo-EM structures of human IP3R3 in different gating states, revealing the molecular mechanisms of activation and inhibition by IP3, Ca2+, and ATP.

bioRxiv · Oct 18, 2021Biophysics

Structure and assembly of CAV1 8S complexes revealed by single particle electron microscopy

B. Han, J. C. Porta, J. L. Hanks, Y. Peskova, E. Binshtein, K. Dryden, D. P. Claxton, H. S. Mchaourab, E. Karakas, M. D. Ohi, A. K. Kenworthy

This study uses single particle electron microscopy to reveal the structure of human CAV1 8S complexes, showing they are toroidal with distinct rings and stalks, and provides insights into their assembly.

bioRxiv · Jun 4, 2020Cell Biology