IL-7R signalling activates widespread VH and DH gene usage to drive antibody diversity in bone marrow B cells
A. Baizan Edge, B. A. Stubbs, M. J. T. Stubbington, D. J. Bolland, K. Tabbada, S. Andrews, A. E. Corcoran
This study shows IL-7R signalling influences VH and DH gene usage in bone marrow B cells, shaping the Igh repertoire through epigenetic mechanisms.
bioRxiv · Sep 24, 2020Immunology