K. Zarnack

Intrinsically disordered RNA-binding motifs cooperate to catalyze RNA folding and drive phase separation

This study identifies PUN motifs in yeast Loc1p that cooperate to catalyze RNA folding and drive phase separation, suggesting a role in RNA and DNA-related processes across species.

A consensus motif in ASH1 and further transcripts unifies several RNA motifs required for interaction with the She2p/She3p transport machinery and mRNA localization in yeast

The paper identifies a consensus motif for She2p/3p recognition sites in yeast RNA, showing that spatial arrangement of sequence features is more important than sequence order for function.

Arid5a uses disordered extensions of its core ARID domain for distinct DNA- and RNA-recognition and gene regulation

This study defines Arid5a's DNA and RNA-binding preferences using biochemical and high-throughput methods, showing that disordered regions modulate its nucleic acid interactions and gene regulation.

Long-read transcriptome sequencing of CLL and MDS patients uncovers molecular effects of SF3B1 mutations

This study uses long-read transcriptome sequencing to analyze SF3B1 mutations in CLL and MDS patients, revealing common splicing alterations and their impact on disease prognosis.

A high-resolution map of functional miR-181 response elements in the thymus reveals the role of coding sequence targeting and an alternative seed match

This study maps miR-181 response elements in murine T-cells, revealing novel targets and an alternative seed match mechanism for miR-181 action.

hGRAD - a versatile 'one-fits-all' system for the acute depletion of RNA binding proteins in nuclear condensates

hGRAD rapidly depletes nuclear RNA binding proteins, enabling study of their roles in RNA processing and dynamics.

Npl3 functions in mRNP assembly by recruitment of mRNP components to the transcription site and their transfer onto the mRNA

The paper identifies Npl3's role in mRNP assembly by recruiting components to the transcription site and transferring them onto mRNA.

Modulation of pre-mRNA structure by hnRNP proteins regulates alternative splicing of MALT1

The paper shows hnRNP proteins modulate MALT1 pre-mRNA structure to regulate alternative splicing of exon7 by competing for RNA stem-loop binding.

Polypyrimidine Tract Binding Proteins are essential for B cell development

This study shows PTBP1 and PTBP2 regulate B cell development by controlling cell cycle progression through mRNA splicing and kinase activity.

The key protein of endosomal mRNP transport Rrm4 binds translational landmark sites of cargo mRNAs