Author

K. Tooley

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 3

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 2 Approach:experimental assay· 2 Organism:human· 2 Organism:mouse· 2 Assay:bulk RNA-seq· 1 Approach:deep learning· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

A. C. Anderson· 3 shared A. Madi· 2 shared A. Regev· 2 shared D. Mangani· 2 shared O. Rozenblatt-Rosen· 2 shared V. K. Kuchroo· 2 shared A. Misra· 1 shared C. Lambden· 1 shared

Activity by Year

2019-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 35 mutual co-author links

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3 shared papersImmunology

A. C. Anderson

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Author profile →

3 papers

Recent·Most cited

Charting the cellular biogeography in colitis reveals fibroblast trajectories and coordinated spatial remodeling

P. Cadinu, K. N. Sivanathan, A. Misra, R. J. Xu, D. Mangani, E. Yang, J. M. Rone, K. Tooley, Y.-C. Kye, L. Bod, L. Geistlinger, T. Lee, N. Ono, G. Wang, L. Sanmarco, , R. Nowarski

The paper uses MERFISH to analyze gene expression in a mouse colitis model, revealing fibroblast trajectories and spatial remodeling during inflammation.

bioRxiv · May 8, 2023Immunology

Pan-cancer mapping of single T cell profiles reveals a TCF1:CXCR6-CXCL16 regulatory axis essential for effective anti-tumor immunity

L. Jerby, K. Tooley, G. Escobar, G. Dandekar, A. Madi, E. Goldschmidt, C. Lambden, O. Rozenblatt-Rosen, A. C. Anderson, A. Regev

The paper identifies a TCF1:CXCR6-CXCL16 regulatory axis critical for anti-tumor immunity by analyzing single-cell RNA-seq data from multiple cancers.

bioRxiv · Oct 31, 2021 · PreprintImmunology

An endogenous glucocorticoid-cytokine signaling circuit promotes CD8+ T cell dysfunction in the tumor microenvironment

N. Acharya, A. Madi, H. Zhang, M. Klapholz, E. Christian, K. O. Dixon, G. Fell, K. Tooley, D. Mangani, J. Xia, M. Singer, D. Neuberg, O. Rozenblatt-Rosen, A. Regev, V. K. Kuchroo, A. C. Anderson

This study identifies a glucocorticoid-cytokine signaling circuit in the tumor microenvironment that promotes CD8+ T cell dysfunction and correlates with poor response to checkpoint blockade in melanoma.

bioRxiv · Oct 10, 2019 · PreprintImmunology