O. Rozenblatt-Rosen

This study identifies a rare progenitor cell population in the human airway that can differentiate into ionocytes or tuft cells, and shows cytokines can shift their lineage towards tuft cells in asthma and CF.

This study constructs a multi-omic atlas of TP53-mutant lung adenocarcinoma tumors, revealing altered cellular identity, gene expression programs, and spatial interactions in the tumor microenvironment.

The paper combines single cell and spatial transcriptomics to map spatial organization and functional interactions in colorectal cancer across species.

The paper analyzes chromatin landscapes of Th17 cell subsets to uncover regulatory mechanisms driving their heterogeneity and identifies BACH2 as a novel regulator of pathogenicity.

The paper identifies a TCF1:CXCR6-CXCL16 regulatory axis critical for anti-tumor immunity by analyzing single-cell RNA-seq data from multiple cancers.

The paper develops a cross-tissue single-nucleus RNA-seq atlas to identify cell types and gene functions in health and disease.

This study uses scRNA-seq and snRNA-seq to analyze 73,295 human liver cells, revealing heterogeneity in hepatic stellate cells, cholangiocytes, and interzonal hepatocytes.

This study identifies a maternal-fetal immune interaction involving KIR2DL1 and HLA-C*05 that causes intrauterine growth restriction in a humanised mouse model.

The paper uses single-cell RNA sequencing to analyze immature human thymocytes and identifies thymus seeding precursors and T-lineage developmental pathways.

The paper introduces MIX-Seq, a method for multiplexed single-cell transcriptional profiling of cancer cell responses to perturbations, revealing drug mechanisms and predicting cell viability.

The paper uses single-cell RNA-seq to analyze cancer cell lines and identifies recurring expression programs of heterogeneity that mirror those in tumors, suggesting intrinsic plasticity contributes to intra-tumoral diversity.

This study identifies a glucocorticoid-cytokine signaling circuit in the tumor microenvironment that promotes CD8+ T cell dysfunction and correlates with poor response to checkpoint blockade in melanoma.

This study identifies FGFR and FGF pathway alterations as acquired resistance mechanisms to ER-targeted therapy in ER+ metastatic breast cancer and suggests targeted inhibitors as potential treatments.

The paper profiles synovial sarcoma tumors to show that the SS18-SSX fusion drives oncogenic programs, which are repressed by immune cells and can be targeted with HDAC and CDK4/6 inhibitors.

The paper defines a cellular taxonomy of mouse bone marrow stroma using single-cell RNA-seq and shows how leukemia disrupts stromal function to impair normal hematopoiesis.