K. Ueda

p53 secures the normal behavior of H3.1 histone in the nucleus by regulating nuclear phosphatidic acid and EZH2 during the G1/S phase

This study shows p53 regulates H3.1 histone behavior during G1/S phase by modulating nuclear phosphatidic acid and EZH2 levels, preventing H3.1 from being trimethylated at the nuclear envelope.

Emergence of linkage between cooperative RNA replicators encoding replication and metabolic enzymes thorough experimental evolution

This study shows that cooperative RNA replicators can evolve into a linked RNA structure in cell-like compartments, supporting the emergence of a primitive chromosome from unlinked genes.

Rational control of structural off-state heterogeneity in a photoswitchable fluorescent protein provides switching contrast enhancement

This paper enhances switching contrast in photoswitchable fluorescent proteins by modifying the V151 side chain, improving performance in RESOLFT nanoscopy.

ABCA1 causes an asymmetric cholesterol distribution to regulate intracellular cholesterol homeostasis

This study identifies ABCA1 and Aster-A as cooperative regulators of PM cholesterol asymmetry to maintain intracellular cholesterol homeostasis.

Fast and ultra-sensitive glycoform analysis by supercritical fluid chromatography-tandem mass spectrometry

This study develops a fast, sensitive SFC-MS/MS method to analyze glycoforms of therapeutic mAbs, detecting 102 glycoforms with a 5 attomole limit and a 6-order dynamic range.

Elevated METTL9 is associated with peritoneal dissemination in human scirrhous gastric cancers

This study identifies METTL9 as a key factor in peritoneal dissemination of scirrhous gastric cancers by showing its role in mitochondrial function and metastatic activity.

Recruitment of Peroxin14 to lipid droplets affects triglyceride storage in Drosophila

The paper investigates the role of Peroxin14 in lipid droplet function in Drosophila, showing its impact on triglyceride storage through interactions with perilipin and lipases.

Comprehensive-immunopeptidomics analysis reveals presentation of potential neoantigens carrying cancer driver mutations

This study identifies neoantigens with cancer driver mutations using immunopeptidomics techniques, revealing new potential targets for cancer immunotherapy.

Suberoyl bis-hydroxamic acid reactivates Kaposis sarcoma-associated herpesvirus through histone acetylation and induces apoptosis in lymphoma cells

This paper shows that SBHA reactivates KSHV in PEL cells through histone acetylation and induces apoptosis via the mitochondrial pathway, suggesting its potential as a therapeutic for PEL.

Emergence and diversification of a host-parasite RNA ecosystem through Darwinian evolution

This study experimentally demonstrates coevolution between host and parasitic RNA molecules, showing how parasitic replicators drive genetic diversity in prebiotic evolution.

The role of ATP hydrolysis in conformational changes of human P-glycoprotein in living cells

This study uses FRET to show ATP binding induces the outward-facing conformation of P-gp, while hydrolysis and {gamma}-phosphate release return it to the inward-facing state in living cells.