H. Hasegawa

This study investigates IgM biosynthesis by analyzing mutant subunits affecting disulfide bonds, revealing the role of non-covalent interactions in IgM assembly and secretion.

This study develops a PA/PAI test to rapidly assess SARS-CoV-2 antigenicity using hACE2-bound latex beads, showing it can detect antigenic differences between variants.

This study investigates reinfection with SARS-CoV-2 Omicron variants in previously infected hamsters, finding that immunity prevents pneumonia but allows viral replication in the upper airways with increased mutation diversity.

This study shows that an intranasal vaccine with CpG ODN2006 induces secretory IgA antibodies against SARS-CoV-2 variants and reduces lung eosinophilic immunopathology compared to subcutaneous vaccination.

The paper compares the efficacy of neutralizing antibodies and antiviral drugs against SARS-CoV-2 Omicron subvariants BA.1 and BA.2, finding differential responses to specific treatments.

This study shows that cynomolgus monkeys with lower peripheral T cell counts experience more severe pneumonia after SARS-CoV-2 infection compared to those with higher T cell counts.

This paper shows that SBHA reactivates KSHV in PEL cells through histone acetylation and induces apoptosis via the mitochondrial pathway, suggesting its potential as a therapeutic for PEL.

This study develops a forecasting framework for influenza A/H3N2 evolution by integrating phenotypic antigenic drift data with sequence-based fitness estimates, showing improved long-term predictions.