The SCP4-STK35/PDIK1L complex is a dual phospho-catalytic signaling dependency in acute myeloid leukemia
S. A. Polyanskaya, R. Y. Moreno, B. Lu, R. Feng, Y. Yao, S. Irani, O. Klingbeil, Z. Yang, Y. Wei, O. E. Demerdash, L. A. Benjamin, M. J. Weiss, Y. Zhang, C. R. Vakoc
This study identifies the SCP4-STK35/PDIK1L phosphatase-kinase complex as a critical signaling dependency in AML, showing its role in proliferation and amino acid metabolism through dual regulatory mechanisms.
bioRxiv · May 9, 2021Cancer Biology