R. Feng

Balance Between EGF/STAT1 and IFNγ/NRF2 Signaling Controls ECM1 Expression and Determines Hepatic Homeostasis versus Chronic Liver Disease

This study identifies EGF/STAT1 and IFNγ/NRF2 signaling pathways regulating ECM1 expression, showing their role in maintaining liver homeostasis versus promoting chronic liver disease.

Retinoic acid generates a beneficial microenvironment for liver progenitor cell activation in acute liver failure

This study shows retinoic acid secreted by activated hepatic stellate cells promotes liver progenitor cell activation in acute liver failure, improving patient outcomes.

ADAR2 inhibits ER-targeted mRNA translation via regulating nucleolar assembly of signal recognition particle

This study shows ADAR2 inhibits ER-targeted mRNA translation by regulating SRP assembly in the nucleolus without requiring RNA binding or A-to-I editing.

PSTPIP2 ameliorates aristolochic acid nephropathy by suppressing interleukin-19-mediated neutrophil extracellular trap formation

This study shows PSTPIP2 reduces kidney damage in AAN by suppressing IL-19-mediated NET formation and inflammation.

Dysregulation of N-terminal acetylation causes cardiac arrhythmia and cardiomyopathy

This study identifies a mutation in NAA10 causing cardiac arrhythmia and cardiomyopathy by disrupting N-terminal acetylation, and shows potential therapeutic interventions.

Single-cell transcriptome analysis on the anatomic positional heterogeneity of pig skin

The paper analyzes single-cell transcriptomes of pig skin from six anatomical regions to characterize cellular heterogeneity and identify candidate genes for ECM accumulation.

Insulin determines the effects of TGF-beta on HNF4alpha transcription and epithelial-to-mesenchymal transition in hepatocytes

This study shows insulin prevents TGF-beta-induced EMT in hepatocytes by inhibiting SMAD2/3 binding to C/EBP and SNAI1 promoters, maintaining HNF4 expression.

Rapid automated 3-D pose estimation of larval zebrafish using a physical model-trained neural network

This paper introduces a method to automatically estimate 3-D poses of larval zebrafish using a neural network trained on synthetic data, achieving high speed and accuracy for ethological studies.

Microbiota-stimulated Interleukin-22 regulates brain neurons and protects against stress-induced anxiety

This study identifies IL-22 as a key immune-to-brain signal that reduces stress-induced anxiety by acting on septal neurons.

BA.2.12.1, BA.4 and BA.5 escape antibodies elicited by Omicron infection

This study investigates antibody evasion by SARS-CoV-2 Omicron sublineages BA.2.12.1, BA.4, and BA.5 against plasma from vaccination and BA.1 infection, showing increased neutralization escape.

Structural and functional characterizations of altered infectivity and immune evasion of SARS-CoV-2 Omicron variant

The paper characterizes structural and functional changes in the SARS-CoV-2 Omicron variant's Spike protein, identifying new immune escape sites and providing insights for vaccine development.

Identification of a MarR subfamily that regulates arsenic resistance genes

This study identifies a novel MarR subfamily, MarRars, that regulates arsenic resistance genes by responding to As(III) and Sb(III) and repressing arsV expression.

The SCP4-STK35/PDIK1L complex is a dual phospho-catalytic signaling dependency in acute myeloid leukemia

This study identifies the SCP4-STK35/PDIK1L phosphatase-kinase complex as a critical signaling dependency in AML, showing its role in proliferation and amino acid metabolism through dual regulatory mechanisms.

Structural and molecular basis for foot-and-mouth disease virus neutralization by two potent protective antibodies

This study identifies the structural and molecular mechanisms of two neutralizing antibodies against FMDV, showing they disrupt virus-receptor interactions and provide prophylactic and therapeutic benefits.

Characterization and structural basis of a lethal mouse-adapted SARS-CoV-2

A mouse-adapted SARS-CoV-2 strain with RBD mutations caused 100% mortality in aged male BALB/c mice and showed altered receptor binding affinity.

Degradation of SARS-CoV-2 receptor ACE2 by tobacco carcinogen-induced Skp2 in lung epithelial cells

The paper shows tobacco carcinogens increase ACE2 mRNA but reduce ACE2 protein levels via Skp2-mediated ubiquitination, decreasing SARS-CoV-2 infection in lung cells.

Single-dose intranasal administration of AdCOVID elicits systemic and mucosal immunity against SARS-CoV-2 in mice

This study shows that AdCOVID, an intranasal vaccine, induces both systemic and mucosal immunity against SARS-CoV-2 in mice.

A proof of concept for neutralizing antibody-guided vaccine design against SARS-CoV-2

A cocktail of neutralizing antibodies targeting SARS-CoV-2 spike protein's NTD and RBD, when used as immunogens in rabbits, elicited strong protective immune responses.