L. A. Mirny

This study shows how 3D genome compartmentalization and enzyme limitation stabilize epigenetic memory through a biophysical model of histone mark spreading.

The paper introduces a physical model of a polymer folded into loops, showing how loops affect contact statistics and reduce topological entanglements in chromosomes.

The paper uses magnetic forces to manipulate a genomic locus in live human cells, revealing chromatin's viscoelastic properties and challenging the gel-like model.

This study investigates how SMC complexes interact when encountering each other on DNA, showing they can traverse, leading to chromosome reorganization and bypassing steric barriers.

The paper shows MCM complexes block cohesin-mediated loop extrusion, reducing CTCF-anchored loops and TAD boundary insulation in G1 phase.

This study investigates how different DNA loop extrusion mechanisms contribute to chromosome compaction, showing that two-sided extrusion and stable binding enhance compaction.

This study investigates one-sided and two-sided loop extrusion by SMC complexes, showing that one-sided extrusion cannot recapitulate in vivo observations but variants can, suggesting SMC complexes may function as two-sided motors or have biased loading.

This study quantitatively investigates how RNA polymerases interact with condensin loop extrusion, showing RNAPs act as steric barriers that impede the process, particularly in highly transcribed regions.

The paper models chromosome compaction by loop-extruding motors and finds one-sided extrusion can only achieve ~10-fold compaction, suggesting other mechanisms are needed for full compaction.