R. Antrobus

Spatial proteomics identifies a novel CRTC-dependent viral sensing pathway that stimulates production of Interleukin-11

The paper identifies a novel CRTC-dependent viral sensing pathway that promotes interleukin-11 production during viral infection.

The role of the AP-1 adaptor complex in outgoing and incoming membrane traffic

The paper investigates AP-1 function in membrane traffic, showing it retrieves proteins from post-Golgi compartments back to the TGN, similar to COPI's role in the early secretory pathway.

HOXA9 forms a repressive complex with nuclear matrix-associated protein SAFB to maintain acute myeloid leukemia

This study identifies a repressive HOXA9-SAFB complex in AML that maintains disease by inhibiting differentiation and apoptosis, suggesting therapeutic targets.

The exocyst complex is an essential component of the mammalian constitutive secretory pathway

This study identifies the exocyst complex as essential for constitutive secretion in mammalian cells by showing its role in carrier fusion and cargo delivery.

Selective modulation of cell surface proteins during vaccinia infection: implications for immune evasion strategies

This study quantifies PM protein modulation during vaccinia infection, identifying downregulated immune ligands and upregulated decoy receptors, revealing immune evasion strategies.

Microbial Nanocellulose Biotextiles for a Circular Materials Economy

This paper develops microbial nanocellulose biotextiles with enhanced mechanical and flame-retardant properties, demonstrating a sustainable alternative to conventional textiles with significantly reduced environmental impact.

IFITM3 regulates virus-induced inflammatory cytokine production by titrating Nogo-B orchestration of TLR responses

This study shows IFITM3 limits viral pathogenesis by regulating Nogo-B-mediated TLR responses and cytokine production in dendritic cells.

Human cytomegalovirus protein RL1 degrades the antiviral factor SLFN11 via recruitment of the CRL4 E3 ubiquitin ligase complex

This study identifies HCMV protein RL1 as a viral antagonist that degrades SLFN11 via CRL4 E3 ubiquitin ligase, revealing SLFN11's role in restricting HCMV infection.

ABHD11 regulates 2-oxoglutarate abundance by protecting mitochondrial lipoylated proteins from lipid peroxidation damage

The paper identifies ABHD11 as a mitochondrial hydrolase that protects lipoylated proteins from lipid peroxidation, thereby regulating 2-OG levels and 2-OG DD function.

Comprehensive cell surface proteomics defines markers of classical, intermediate and non-classical monocytes

The paper identifies cell surface protein markers for classical, intermediate, and non-classical monocytes using mass spectrometry and biotinylation.

Structure of herpes simplex virus pUL7:pUL51, a conserved complex required for efficient herpesvirus assembly

This paper solves the structure of the HSV-1 pUL7:pUL51 complex, showing its conservation across herpesviruses and its potential role in membrane remodeling during virus assembly.

Herpes simplex virus-1 pUL56 degrades GOPC to alter the plasma membrane proteome

This study identifies HSV-1 pUL56 as a protein that degrades GOPC, altering the plasma membrane proteome by affecting signaling receptors.

Integrative functional genomics decodes herpes simplex virus 1

This study decodes the complete HSV-1 transcriptome and translatome during lytic infection, identifying novel transcripts, ORFs, and regulatory elements.

Temporal proteomic analysis of BK polyomavirus infection reveals virus-induced G2 arrest and highly effective evasion of innate immune sensing

This study uses temporal proteomic analysis to show BKPyV induces G2 arrest and evades innate immune sensing during infection.

CHCHD4 confers metabolic vulnerabilities to tumour cells through its control of the mitochondrial respiratory chain.

This study shows CHCHD4 enhances tumor cell survival by regulating mitochondrial respiratory chain function, making tumor cells more vulnerable to inhibition of complex I.

Loss And Gain Of Function Experiments Implicate TMEM18 As A Mediator Of The Strong Association Between Genetic Variants At Human Chromosome 2p25.3 And Obesity

The paper identifies TMEM18 as a mediator of genetic variants at 2p25.3 associated with obesity through loss and gain of function experiments in mice.