Author

F. Erhard

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 6 Cancer Biology· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Organism:human· 6 Approach:statistical model· 5 Assay:bulk RNA-seq· 4 Approach:experimental assay· 3 Research Focus:gene regulatory network inference· 3 Research Focus:host-pathogen & immune response· 3 Approach:deep learning· 2 Research Focus:differential expression· 2

Frequent Co-Authors

B. Prusty· 4 shared L. Dölken· 4 shared T. Hennig· 4 shared A. Grothey· 2 shared A. J. Rutkowski· 2 shared A. L'Hernault· 2 shared A. W. Whisnant· 2 shared C. C. Friedel· 2 shared

Activity by Year

2019-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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4 shared papersMicrobiology

B. Prusty

Mutual co-authors in cluster

Author profile →

8 papers

Recent·Most cited

Multimodal HLA-I genotype regulation by human cytomegalovirus US10 and resulting surface patterning

C. Gerke, L. Bauersfeld, V. Oberhardt, C. Jürges, R. Spaapen, C. Mussolino, V. T. K. Le-Trilling, M. Trilling, L. Dölken, F. Erhard, M. Hofmann, H. Hengel, F. Momburg, A. Halenius

This study investigates how HCMV US10 protein regulates HLA-I genotype and surface expression, revealing its multimodal effects on different HLA-I allotypes.

bioRxiv · Jan 10, 2023Microbiology

Decoding murine cytomegalovirus

M. Lodha, I. Muchsin, C. Jürges, V. Juranic Lisnic, A. L'Hernault, A. Rutkowski, B. Prusty, A. Grothey, A. Milic, T. Hennig, S. Jonjic, C. Friedel, F. Erhard, L. Doelken

This paper reannotates MCMV gene expression using multi-omics data, identifying hundreds of novel transcripts and ORFs, including small ORFs that regulate gene expression and a new immediate-early transcript.

bioRxiv · Nov 10, 2022 · PreprintMicrobiology

Immunogenicity of non-canonical HLA-tumor ligands identified through proteogenomics

M. Lozano-Rabella, A. Garcia-Garijo, J. Palomero, A. Yuste-Estevanez, F. Erhard, J. Martin-Liberal, M. Ochoa de Olza, I. Matos, J. J. Gartner, M. Ghosh, F. Canals, A. Vidal, J. M. Piulats, X. Matias-Guiu, I. Brana, , A. Gros

The paper investigates the immunogenicity of non-canonical HLA-I ligands from tumor cells and finds they are not recognized by autologous T-cells but can be targeted by donor T-cells, suggesting potential as immunotherapy targets.

bioRxiv · Nov 7, 2022Cancer Biology

Multi-omics reveals principles of gene regulation and pervasive non-productive transcription in the human cytomegalovirus genome

C. S. Jürges, M. Lodha, V. T. K. Le-Trilling, P. Bhandare, E. Wolf, A. Zimmermann, M. Trilling, B. Prusty, L. Dölken, F. Erhard

The paper uses multi-omics data to model HCMV gene regulation, identifying over 2,600 viral transcripts and explaining protein expression kinetics through transcription start sites and RNA stability.

bioRxiv · Jan 7, 2022 · PreprintMicrobiology

pUL36 de-ubiquitinase activity augments both the initiation and progression of lytic virus infection in IFN-primed cells

J. Mohnke, I. Stark, M. Fischer, A. Grothey, P. O'Hare, B. Sodeik, F. Erhard, L. Dölken, T. Hennig

This study shows that pUL36 DUB activity helps HSV-1 overcome IFN resistance and enhance lytic infection in IFN-primed cells.

bioRxiv · Jan 29, 2021 · PreprintMicrobiology

Integrated scRNA-seq analysis identifies conserved transcriptomic features of mononuclear phagocytes in mouse and human atherosclerosis

A. Zernecke, F. Erhard, T. Weinberger, C. Schulz, K. Ley, A.-E. Saliba, C. Cochain

This study integrates scRNA-seq data from mouse and human atherosclerosis to identify conserved transcriptomic features of mononuclear phagocytes across species.

bioRxiv · Dec 9, 2020Immunology

Dissecting HSV-1-induced host shut-off at RNA level

C. C. Friedel, A. W. Whisnant, L. Djakovic, A. J. Rutkowski, M.-S. Friedl, M. Kluge, J. C. Williamson, S. Sai, R. O. Vidal, S. Sauer, T. Hennig, B. Prusty, P. J. Lehner, N. J. Matheson, F. Erhard, L. Dölken

This study quantifies HSV-1-induced host shut-off mechanisms and identifies gene-specific transcriptional changes during early infection.

bioRxiv · May 20, 2020 · PreprintMicrobiology

Integrative functional genomics decodes herpes simplex virus 1

A. W. Whisnant, C. S. Juerges, T. Hennig, E. Wyler, B. Prusty, A. J. Rutkowski, A. L'Hernault, M. Goebel, K. Doering, J. Menegatti, R. Antrobus, N. J. Matheson, F. W. Kuenzig, G. Mastrobuoni, C. Bielow, , L. Doelken

This study decodes the complete HSV-1 transcriptome and translatome during lytic infection, identifying novel transcripts, ORFs, and regulatory elements.

bioRxiv · Apr 9, 2019Microbiology