Inadequate structural constraint on Fab approach rather than paratope elicitation limits HIV-1 MPER vaccine utility
K. Tan, J. Chen, Y. Kaku, Y. Wang, L. Donius, R. A. Khan, X. Li, H. Richter, M. S. Seaman, T. Walz, W. Hwang, E. L. Reinherz, M. Kim
The paper shows that HIV-1 MPER-targeting antibodies generated by vaccines lack structural constraints needed to access the MPER, despite having bnAb-like paratopes.
bioRxiv · Jun 27, 2023Immunology