T. Walz

The resting and ligand-bound states of the membrane-embedded human T-cell receptor-CD3 complex

This study presents cryo-EM structures of the human TCR-CD3 complex in its resting and ligand-bound states, revealing conformational changes and the importance of native lipid environments.

Inadequate structural constraint on Fab approach rather than paratope elicitation limits HIV-1 MPER vaccine utility

The paper shows that HIV-1 MPER-targeting antibodies generated by vaccines lack structural constraints needed to access the MPER, despite having bnAb-like paratopes.

Structure and dynamics of cholesterol-mediated aquaporin-0 arrays and implications for lipid rafts

This study determines the structure of AQP0 tetramers in sphingomyelin/cholesterol membranes and shows how cholesterol stabilizes their arrangement through hydrophobic interactions and avidity effects.

POT1 recruits and regulates CST-Polα/Primase at human telomeres

This study determines the structure of human CST bound to POT1/TPP1, revealing how POT1 recruits and regulates CST-Polα/Primase at telomeres through phosphorylation-dependent interactions.

Dynamic HIV-1 spike motion creates vulnerability for its membrane-bound tripod to antibody attack

The paper investigates HIV-1 spike protein dynamics using cryo-EM and simulations, showing how tilting exposes the MPER to antibody attack and alters membrane fusion.

Shelterin is a Dimeric Complex with Extensive Structural Heterogeneity

This study characterizes the structural architecture and conformational variability of the human shelterin complex using multiple biophysical methods.

Cryo-EM structure of the human CST·Polα/Primase complex in a recruitment state

The paper presents a cryo-EM structure of the human CST·Polα/Primase complex in a recruitment state, revealing its architecture and informing on disease mutations.

Cyclodextrins increase membrane tension and are universal activators of mechanosensitive channels

This study shows cyclodextrins activate mechanosensitive channels by mimicking membrane tension through lipid removal, revealing a universal mechanism for channel activation.

Structural asymmetry governs the assembly and GTPase activity of McrBC restriction complexes

This study reports cryo-EM structures of McrBC complexes from different bacteria, revealing structural asymmetry that governs GTPase activity and nuclease function.

Near-atomic structures of the BBSome reveal a novel mechanism for transition zone crossing

The paper reveals how the BBSome facilitates GPCR transport across the transition zone by extracting amphipathic helices from the inner leaflet of the membrane.

PRC2 bridges non-adjacent nucleosomes to establish heterochromatin

This study investigates how PRC2 interacts with chromatin using single-molecule force spectroscopy and simulations, revealing new binding configurations and their regulation.

Novel Pure αVβ3 Integrin Antagonists That Do Not Induce Receptor Extension, Prime the Receptor, or Enhance Angiogenesis at Low Concentrations

This paper designs and evaluates two small-molecule Vβ3 antagonists that inhibit cell adhesion and bone resorption without inducing receptor conformational changes or enhancing angiogenesis at low concentrations.

Molecular basis for the recognition of the human AAUAAA polyadenylation signal

The paper determines the cryo-EM structure of a human polyadenylation complex bound to AAUAAA RNA, revealing how this signal is recognized by CPSF-30 and WDR33.

Visualization of ligand-induced transmembrane signalling in the full-length human insulin receptor

The paper visualizes how insulin binding changes the structure of the human insulin receptor, leading to autophosphorylation.