W. Hwang

Asymmetric framework motion of TCR alpha beta controls load-dependent peptide discrimination

The paper uses molecular dynamics simulations to show how asymmetric motion of TCR alpha beta chains affects peptide discrimination under mechanical force.

Inadequate structural constraint on Fab approach rather than paratope elicitation limits HIV-1 MPER vaccine utility

The paper shows that HIV-1 MPER-targeting antibodies generated by vaccines lack structural constraints needed to access the MPER, despite having bnAb-like paratopes.

Pre-T cell receptor Self-MHC Sampling Restricts Thymocyte Dedifferentiation

The paper shows that preTCR-pMHC interactions prevent thymocyte dedifferentiation by analyzing single-cell transcriptomes in fetal thymic cultures with and without pMHC.

Intercellular CRISPR Screens Enhance the Discovery of Cancer Immunotherapy Targets

This paper introduces intercellular CRISPR screens to identify cancer immunotherapy targets by analyzing interactions between immune and cancer cells, finding improved target discovery compared to single-cell screens.

Cryptic diversity within the Poecilochirus carabi mite species complex phoretic on Nicrophorus burying beetles: phylogeny, biogeography, and host specificity

This study identifies cryptic diversity within the Poecilochirus carabi mite species complex using molecular data, revealing multiple genetic clusters and suggesting diversification driven by geographic separation and host adaptation.

A Robust Genome-Wide Association Study Uncovers Signature Genetic Alterations among Pseudomonas aeruginosa Cystic Fibrosis Isolates

This study performs a genome-wide association study on Pseudomonas aeruginosa isolates from cystic fibrosis patients and identifies genetic alterations specific to these isolates.

Identification of SARS-CoV-2 induced pathways reveal drug repurposing strategies

The paper identifies 200 approved drugs that target SARS-CoV-2-induced pathways, with 40 in clinical trials, and classifies them into viral replication and immune response mechanisms.

Quantifying the Heat Dissipation from Molecular Motor’s Transport Properties in Nonequilibrium Steady States

The paper quantifies heat dissipation from molecular motors in nonequilibrium steady states and links it to transport properties like velocity and diffusivity.

Decoding Single Molecule Time Traces with Dynamic Disorder

This paper introduces VB-DCMM, an algorithm to analyze single molecule time trajectories with dynamic disorder, and applies it to H-DNA FRET data to reveal multiple internal states and kinetic paths.