L. Faivre

Humanized in vivo bone marrow models orchestrate multi-lineage human hematopoietic cell development

This study characterizes a humanized in vivo bone marrow model, hOss, showing its impact on human hematopoietic development and clonal interactions.

heterotypic interaction promotes asymmetric division of human hematopoietic stem and progenitor cells

This study shows that interaction with osteoblasts promotes asymmetric division of human HSPCs, leading to unequal inheritance of lysosomes and differentiation markers.

Non-pathogenic leaf-colonising bacteria elicit pathogen-like responses in a colonisation density-dependent manner

The paper shows that non-pathogenic bacteria cause pathogen-like plant responses depending on their density, with high titers triggering strong defense mechanisms.

Self-organization of Long-lasting Human Endothelial Capillary Networks guided by DLP Bioprinting

This paper uses DLP bioprinting to guide endothelial cells into self-organizing vascular networks, demonstrating stable capillary-like structures with various geometries.

ANKRD26 is a new regulator of type I cytokine receptor signaling in normal and pathological hematopoiesis

This study identifies ANKRD26 as a regulator of type I cytokine receptor signaling in hematopoiesis, showing its role in progenitor proliferation and differentiation.

Mutations in SKI in Shprintzen-Goldberg syndrome lead to attenuated TGF-β responses through SKI stabilization

This study shows that SGS mutations in SKI prevent its binding to phosphorylated SMAD2/3, leading to SKI stabilization and reduced TGF-β responses.

Hematopoietic progenitors polarize in contact with bone marrow stromal cells by engaging CXCR4 receptors.

This study shows that hematopoietic progenitors polarize when in contact with bone marrow stromal cells via CXCR4 receptors, leading to cytoskeletal reorganization and centrosome-microtubule network polarization.

Microtubules deform the nucleus and force chromatin reorganization during early differentiation of human hematopoietic stem cells.

The paper shows microtubules cause nuclear invaginations and chromatin reorganization in human HSCs during myeloid differentiation, linking nuclear shape to gene expression changes.

Transcriptional and post-transcriptional regulation and transcriptional memory of chromatin regulators in response to low temperature

The paper profiles chromatin gene regulation in response to low temperature stress and reveals transcriptional and post-transcriptional changes, including alternative splicing, during deacclimation.