Author

L. Farnung

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 4 Biophysics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Research Focus:chromatin & epigenetic regulation· 3 Organism:yeast· 3 Assay:structural biology· 2 Assay:ChIP-seq· 1 Assay:cryo-EM· 1 Research Focus:host-pathogen & immune response· 1 Approach:microscopy & imaging analysis· 1

Frequent Co-Authors

P. Cramer· 5 shared C. Dienemann· 2 shared D. Tegunov· 2 shared G. Kokic· 2 shared H. S. Hillen· 2 shared A. Schmid· 1 shared A. Siewert· 1 shared C. Hoebartner· 1 shared

Activity by Year

2018-2020 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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5 shared papersBiochemistry

P. Cramer

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Structural basis of nucleosome transcription mediated by Chd1 and FACT

L. Farnung, M. Ochmann, M. Engeholm, P. Cramer

This paper determines cryo-EM structures of Pol II-Spt4/5-nucleosome complexes with bound Chd1 or FACT, revealing their roles in facilitating Pol II passage through nucleosomes.

bioRxiv · Nov 30, 2020Biochemistry

Mechanism of SARS-CoV-2 polymerase inhibition by remdesivir

G. Kokic, H. S. Hillen, D. Tegunov, C. Dienemann, F. Seitz, J. Schmitzova, L. Farnung, A. Siewert, C. Hoebartner, P. Cramer

This study elucidates how remdesivir inhibits SARS-CoV-2 RNA-dependent RNA polymerase by causing RNA synthesis stalling through a translocation barrier.

bioRxiv · Oct 28, 2020Biochemistry

Structure of replicating SARS-CoV-2 polymerase

H. S. Hillen, G. Kokic, L. Farnung, C. Dienemann, D. Tegunov, P. Cramer

This study presents the cryo-EM structure of the SARS-CoV-2 RdRp complex, revealing its mechanism of RNA replication and potential antiviral targets.

bioRxiv · Apr 27, 2020Biophysics

Ruler elements in chromatin remodelers set nucleosome array spacing and phasing

E. Oberbeckmann, V. Niebauer, S. Watanabe, L. Farnung, M. Moldt, A. Schmid, P. Cramer, C. L. Peterson, S. Eustermann, K.-P. Hopfner, P. Korber

The paper identifies a ruler element in chromatin remodelers that determines nucleosome spacing and phasing in Saccharomyces cerevisiae.

bioRxiv · Feb 28, 2020Biochemistry

Structure of transcribing RNA polymerase II-nucleosome complex

L. Farnung, S. M. Vos, P. Cramer

The paper reports the cryo-EM structure of transcribing RNA polymerase II engaged with a nucleosome in yeast, revealing interactions and potential mechanisms for chromatin transcription.

bioRxiv · Oct 16, 2018Biochemistry