Author

H. S. Hillen

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Biophysics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:virus· 2 Approach:biophysical modeling· 1 Research Focus:chromatin & epigenetic regulation· 1 Assay:cryo-EM· 1 Research Focus:host-pathogen & immune response· 1 Research Focus:protein structure prediction· 1 Assay:proteomics· 1

Frequent Co-Authors

C. Dienemann· 3 shared P. Cramer· 3 shared D. Tegunov· 2 shared G. Kokic· 2 shared J. Schmitzova· 2 shared L. Farnung· 2 shared A. Siewert· 1 shared C. Höbartner· 1 shared

Activity by Year

2020-2021 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 35 mutual co-author links

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3 shared papersBiochemistry

C. Dienemann

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

BiochemistrybioRxivMay 11, 2021

Mechanism of molnupiravir-induced SARS-CoV-2 mutagenesis

F. Kabinger, C. Stiller, J. Schmitzova…·P. Cramer

This paper identifies the molecular mechanism by which molnupiravir induces SARS-CoV-2 RNA mutations through its interaction with the viral RNA-dependent RNA polymerase.

DOI 10.1038/s41594-021-00651-0

virusproteomics

𝕏 PostBluesky

BiochemistrybioRxivOct 28, 2020

Mechanism of SARS-CoV-2 polymerase inhibition by remdesivir

G. Kokic, H. S. Hillen, D. Tegunov…·P. Cramer

This study elucidates how remdesivir inhibits SARS-CoV-2 RNA-dependent RNA polymerase by causing RNA synthesis stalling through a translocation barrier.

DOI 10.1038/s41467-020-20542-0

experimental assayhost-pathogen & immune response

𝕏 PostBluesky

BiophysicsbioRxivApr 27, 2020

Structure of replicating SARS-CoV-2 polymerase

H. S. Hillen, G. Kokic, L. Farnung…·P. Cramer

This study presents the cryo-EM structure of the SARS-CoV-2 RdRp complex, revealing its mechanism of RNA replication and potential antiviral targets.

DOI 10.1038/s41586-020-2368-8

viruscryo-EM

𝕏 PostBluesky