Author

D. Tegunov

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 4 Biochemistry· 2 Plant Biology· 1

Signature Assays, Organisms & Methods

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Assay:cryo-EM· 5 Approach:experimental assay· 3 Research Focus:protein structure prediction· 3 Organism:bacteria (other)· 2 Research Focus:cell type annotation· 2 Approach:deep learning· 2 Approach:microscopy & imaging analysis· 2 Research Focus:spatial domain detection· 2

Frequent Co-Authors

P. Cramer· 5 shared C. Dienemann· 3 shared G. Kokic· 2 shared H. S. Hillen· 2 shared J. Mahamid· 2 shared L. Farnung· 2 shared L. Xue· 2 shared W. Baumeister· 2 shared

Activity by Year

2016-2021 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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5 shared papersBiophysics

P. Cramer

Mutual co-authors in cluster

Author profile →

7 papers

Recent·Most cited

Visualizing translation dynamics at atomic detail inside a bacterial cell

L. Xue, S. Lenz, M. Zimmermann-Kogadeeva, D. Tegunov, P. Cramer, P. Bork, J. Rappsilber, J. Mahamid

This study uses cryo-electron tomography to visualize translation dynamics in Mycoplasma pneumoniae, revealing ribosome states and showing how antibiotics affect translation.

bioRxiv · Dec 18, 2021Biochemistry

Mechanism of SARS-CoV-2 polymerase inhibition by remdesivir

G. Kokic, H. S. Hillen, D. Tegunov, C. Dienemann, F. Seitz, J. Schmitzova, L. Farnung, A. Siewert, C. Hoebartner, P. Cramer

This study elucidates how remdesivir inhibits SARS-CoV-2 RNA-dependent RNA polymerase by causing RNA synthesis stalling through a translocation barrier.

bioRxiv · Oct 28, 2020Biochemistry

Multi-particle cryo-EM refinement with M visualizes ribosome-antibiotic complex at 3.7 A inside cells

D. Tegunov, L. Xue, C. Dienemann, P. Cramer, J. Mahamid

The paper introduces a software tool, M, for multi-particle cryo-EM refinement that achieves 3.7 Å resolution of a ribosome-antibiotic complex inside bacterial cells.

bioRxiv · Jun 5, 2020Biophysics

Structure of replicating SARS-CoV-2 polymerase

H. S. Hillen, G. Kokic, L. Farnung, C. Dienemann, D. Tegunov, P. Cramer

This study presents the cryo-EM structure of the SARS-CoV-2 RdRp complex, revealing its mechanism of RNA replication and potential antiviral targets.

bioRxiv · Apr 27, 2020Biophysics

Charting the native architecture of thylakoid membranes with single-molecule precision

W. Wietrzynski, M. Schaffer, D. Tegunov, S. Albert, A. Kanazawa, J. M. Plitzko, W. Baumeister, B. D. Engel

The paper uses cryo-electron tomography to map the native molecular landscape of thylakoid membranes in green algae, revealing segregation of photosystems I and II at membrane domain borders.

bioRxiv · Sep 5, 2019Plant Biology

Real-time cryo-EM data pre-processing with Warp

D. Tegunov, P. Cramer

Warp processes cryo-EM data in real-time during acquisition, improving resolution and automating pre-processing steps.

bioRxiv · Jun 14, 2018Biophysics

Using the Volta phase plate with defocus for cryo-EM single particle analysis

R. Danev, D. Tegunov, W. Baumeister

This paper extends the use of the Volta phase plate in cryo-EM by incorporating defocus to improve data acquisition and achieve high-resolution 3D reconstructions.

bioRxiv · Nov 3, 2016Biophysics