Defining RNA oligonucleotides that reverse deleterious phase transitions of RNA-binding proteins with prion-like domains
L. Guo, J. R. Mann, J. C. Mauna, K. E. Copley, H. Wang, J. D. Rubien, H. M. Odeh, J. Lin, B. L. Lee, L. Ganser, E. Robinson, K. M. Kim, A. C. Murthy, T. Paul, B. Portz, , J. Shorter
The paper identifies short RNAs that prevent and reverse pathological fibrillization of RNA-binding proteins like FUS and TDP-43, showing therapeutic potential for ALS/FTD.
bioRxiv · Sep 4, 2023Biochemistry