Author

C. Espy

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioengineering· 3 Biochemistry· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 4 Approach:experimental assay· 4 Organism:human· 3 Organism:mouse· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1

Frequent Co-Authors

J. S. Brenner· 3 shared J. Wu· 3 shared M. N. Patel· 3 shared S. Omo-Lamai· 3 shared E.-O. Essien· 2 shared J. W. Myerson· 2 shared L. S. Chase· 2 shared M. E. Zamora· 2 shared

Activity by Year

2023-2024 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersBioengineering

J. S. Brenner

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Enabling non-viral DNA delivery using lipid nanoparticles co-loaded with endogenous anti-inflammatory lipids

M. N. Patel, S. Tiwari, Y. Wang, S. O'Neill, J. Wu, S. Omo-Lamai, C. Espy, L. S. Chase, A. Majumdar, E. Hoffman, A. Shah, A. Sarkozy, J. Katzen, N. Pardi, J. S. Brenner

This study develops lipid nanoparticles co-loaded with anti-inflammatory lipids to reduce inflammation from DNA delivery, enabling prolonged transgene expression.

bioRxiv · Jun 11, 2024Bioengineering

Marginated neutrophils in the lungs effectively compete for nanoparticles targeted to the endothelium, serving as a part of the reticuloendothelial system

M. E. Zamora, E.-O. Essien, K. Bhamidipati, A. Murthy, J. Liu, H. Kim, M. N. Patel, J. Nong, Z. Wang, C. Espy, F. Chaudhry, L. T. Ferguson, S. Tiwari, E. Hood, O. A. Marcos-Contreras, , J. S. Brenner

The paper shows that lung marginated neutrophils effectively uptake endothelial-targeted nanoparticles, suggesting they are part of the reticuloendothelial system.

bioRxiv · Jun 7, 2024Bioengineering

Lipid Nanoparticle-Associated Inflammation is Triggered by Sensing of Endosomal Damage: Engineering Endosomal Escape without Side Effects

S. Omo-Lamai, Y. Wang, M. N. Patel, E.-o. Essien, M. Shen, A. Majumder, C. Espy, J. Wu, B. Channer, M. P. Tobin, S. Murali, T. E. Papp, R. Maheshwari, L. Wang, L. S. Chase, , J. S. Brenner

This paper identifies that lipid nanoparticle-induced inflammation arises from endosomal membrane damage and proposes strategies to mitigate it through galectin inhibition or ESCRT-recruiting lipids.

bioRxiv · Apr 16, 2024 · PreprintBioengineering

Defining RNA oligonucleotides that reverse deleterious phase transitions of RNA-binding proteins with prion-like domains

L. Guo, J. R. Mann, J. C. Mauna, K. E. Copley, H. Wang, J. D. Rubien, H. M. Odeh, J. Lin, B. L. Lee, L. Ganser, E. Robinson, K. M. Kim, A. C. Murthy, T. Paul, B. Portz, , J. Shorter

The paper identifies short RNAs that prevent and reverse pathological fibrillization of RNA-binding proteins like FUS and TDP-43, showing therapeutic potential for ALS/FTD.

bioRxiv · Sep 4, 2023Biochemistry