Author

T. Paul

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 3 Biochemistry· 1 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell signaling & trafficking· 3 Approach:experimental assay· 3 Organism:human· 3 Research Focus:drug response / drug discovery· 2 Research Focus:benchmarking· 1 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Approach:deep learning· 1

Frequent Co-Authors

S. Myong· 2 shared A. C. Murthy· 1 shared A. Chesi· 1 shared A. K. Leung· 1 shared A. Kraut· 1 shared A. L. Kenet· 1 shared A. M. Gleixner· 1 shared A. Smirnov· 1 shared

Activity by Year

2022-2023 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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2 shared papersBiochemistry

S. Myong

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

A stochastic population model for the impact of cancer cell dormancy on therapy success

J. Blath, A. Kraut, T. Paul, A. Tobias

This paper introduces a stochastic agent-based model to study how cancer cell dormancy affects therapy success, showing that even small dormant cell populations can lead to treatment failure.

bioRxiv · Dec 15, 2023Cancer Biology

Unearthing SRSF1's Novel Function in Binding and Unfolding of RNA G-Quadruplexes

N. I. U. De Silva, N. Lehman, T. E. Fargason, T. Paul, Z. Zhang, J. Zhang

This study identifies SRSF1's novel ability to bind and unfold RNA G-quadruplexes, revealing new roles for its RS domain in RNA regulation.

bioRxiv · Oct 30, 2023 · PreprintBiophysics

Defining RNA oligonucleotides that reverse deleterious phase transitions of RNA-binding proteins with prion-like domains

L. Guo, J. R. Mann, J. C. Mauna, K. E. Copley, H. Wang, J. D. Rubien, H. M. Odeh, J. Lin, B. L. Lee, L. Ganser, E. Robinson, K. M. Kim, A. C. Murthy, T. Paul, B. Portz, , J. Shorter

The paper identifies short RNAs that prevent and reverse pathological fibrillization of RNA-binding proteins like FUS and TDP-43, showing therapeutic potential for ALS/FTD.

bioRxiv · Sep 4, 2023Biochemistry

Switch-like Compaction of Poly(ADP-ribose) Upon Cation Binding

M. Badiee, A. L. Kenet, L. R. Ganser, T. Paul, S. Myong, A. K. Leung

This study shows PAR is stiffer than DNA/RNA and undergoes switch-like compaction in response to cation binding and protein interactions.

bioRxiv · Mar 11, 2023 · PreprintBiophysics

Single-molecule fluorescence microscopy demonstrates fast dynamics of the variant surface glycoprotein coat on living trypanosomes

M. Schwebs, T. Paul, M. Glogger, L. Forster, B. Morriswood, J. Tessmar, J. Groll, M. Engstler, P. Kollmannsberger, S. Fenz

The paper uses single-molecule tracking to show that VSG coat dynamics on trypanosomes are primarily diffusive with a high diffusion coefficient, resolving how the parasite maintains its coat.

bioRxiv · Aug 3, 2022 · PreprintBiophysics