Cell BiologybioRxiv
Antigen-derived peptides directly engage the unfolded-protein sensor IRE1α to curb cross-presentation by dendritic cells
O. Guttman, A. Le Thomas, S. A. Marsters…·A. Ashkenazi
The paper shows antigen-derived peptides activate IRE1α in dendritic cells, reducing MHC-I expression and cross-presentation, and demonstrates that IRE1 inhibition enhances anti-tumor immunity.
DOI 10.1083/jcb.202111068