A. Murthy

Molecular surface mimicry enables CRBN to target G3BP2 for degradation

This study identifies a novel binding mechanism of G3BP2 to CRBN through an unconventional site, expanding the understanding of CRBN's neosubstrate recognition.

Aberrant Transitional Alveolar Epithelial Cells Promote Pathogenic Activation of Lung Fibroblasts in Preclinical Fibrosis Modeling

This study identifies aberrant transitional alveolar epithelial cells in a mouse fibrosis model and shows they activate fibroblasts through a profibrotic secretome.

Marginated neutrophils in the lungs effectively compete for nanoparticles targeted to the endothelium, serving as a part of the reticuloendothelial system

The paper shows that lung marginated neutrophils effectively uptake endothelial-targeted nanoparticles, suggesting they are part of the reticuloendothelial system.

Systematic perturbation screens decode regulators of inflammatory macrophage states and identify a role for TNF mRNA m6A modification

The paper identifies regulators of inflammatory macrophage states and shows that TNF mRNA m6A modification controls its stability and contributes to disease.

Restoring adiponectin via rosiglitazone ameliorates tissue wasting in mice with lung cancer.

This study shows that rosiglitazone restores adiponectin levels and preserves tissue mass in mice with lung cancer by enhancing AMPK and AKT activity.

A molecular mechanism for membrane chaperoning by a late embryogenesis abundant protein

This paper identifies HeLEA1, a tardigrade LEA protein that acts as a mitochondrial membrane chaperone, improving stress tolerance in yeast by stabilizing lipid packing and reducing surface tension.

Antigen-derived peptides directly engage the unfolded-protein sensor IRE1α to curb cross-presentation by dendritic cells

The paper shows antigen-derived peptides activate IRE1α in dendritic cells, reducing MHC-I expression and cross-presentation, and demonstrates that IRE1 inhibition enhances anti-tumor immunity.

Proteomics of autophagy deficient macrophages reveals enhanced antimicrobial immunity via the oxidative stress response

This study shows that loss of Atg16l1 in macrophages enhances antimicrobial immunity against Shigella flexneri via the oxidative stress response.

Rapid genomic expansion and purging associated with habitat transitions in a clade of beach crustaceans (Haustoriidae: Amphipoda)

This study examines genome size variation in a clade of amphipods, finding a 6-fold variation linked to body length and LINE element expansions, with evidence of genomic purging in lineages adapting to brackish waters.

Implicit perceptual memory can increase or decrease with ageing

This study examines how implicit perceptual memory changes with age and cognitive impairment, finding it can both increase and decrease, independent of explicit memory.