Tumor pre-conditioning of draining lymph node stroma by lactic acid
A. Riedel, J. Swietlik, D. Shorthouse, L. Haas, T. Young, A. S. H. Costa, S. Davidson, L. Pedro, T. Oskarsson, B. A. Hall, C. Frezza, J. Shields
This study identifies lactate as a tumor-derived metabolite that reprograms fibroblastic reticular cells in draining lymph nodes, altering their function and similarity to tumor-associated fibroblasts.
bioRxiv · Oct 12, 2018Cancer Biology