L. M. Ellerby

This study identifies RECS1 as a structural component of the exosomal trafficking machinery and shows it modulates extracellular vesicle biogenesis through a channel-independent mechanism.

The paper introduces PickliPy, an open-source framework for converting assay designs into ADE picklists, enabling reproducible and scalable microplate-based experiments.

The paper identifies senescent fibroblast heterogeneity in IPF and links it to DNA damage response dysregulation using gene expression analysis.

The paper proposes the Decoherence via Demyelination Hypothesis (DDH) to explain age-related cognitive decline through tract-specific myelin loss and its impact on neural network coordination.

This study shows APOE4 affects female bone quality more than male bone, without structural changes, by disrupting osteocyte function.

This study shows DNA damage in neurons leads to a senescent-like state similar to Alzheimer's disease, with distinct features from fibroblasts.

The paper identifies CXXC4 as an epigenetic target that can restore DRD1 striatal neuron activity in Huntington disease by leveraging age-related gene patterns.

This paper develops a proteomic workflow using data-independent acquisitions to analyze APOE3-derived neurons and microglia, identifying cell type-specific markers and pathways.

Gly-Low compounds reduce glycation, lower food intake, improve insulin sensitivity, and extend lifespan in mice by inhibiting ghrelin signaling and enhancing mTOR pathways.

This study uses single-cell RNA sequencing to identify immune changes in the colon of Alzheimer's disease mice, finding reduced antibody-secreting cells and altered immune trafficking.

The paper shows that Huntingtin (HTT) helps maintain mitochondrial DNA integrity by organizing a repair complex, which is disrupted by mutant HTT in Huntington's disease, leading to DNA damage and motor deficits in a fly model.

This study examines intervertebral disc (IVD) impairments in a mouse model of Alzheimer's Disease, finding no increased degeneration but altered mechanical properties and volume.

The paper examines aneuploidy in non-neuronal brain nuclei of GBM patients and finds it is common in normal tissue and not associated with GBM risk.

This study shows that a cyclic ketogenic diet reduces neuroinflammation in aging mice by modulating microglial responses to inflammatory stimuli.

This study shows that deleting TYROBP in HD mice reduces microglial activation and improves motor deficits without correcting neuronal gene expression.

The paper uses single-cell RNA sequencing to study Huntington's disease by analyzing medium spiny neuron development in HD iPSC models and identifies potential therapeutic molecules.

The paper performs proteomic analysis of Huntington's disease patient-derived medium spiny neurons, identifying altered lipid metabolism and lipid droplet accumulation as key findings.

The paper identifies Foxf2 and Olig2 as key transcription factors regulating striatal compartmentation and neuronal differentiation through RNA- and ATAC-seq analysis of murine striosomes and matrix.

The paper uses scRNA-seq to show increased transcriptional heterogeneity in neurodegenerative disease models, suggesting early regulatory imbalances.

This study identifies IGF2 as a disease modifier that reduces intracellular protein aggregates by promoting their extracellular disposal in Huntington's disease models.