L. M. Loew

The paper measures the solubility product in a model condensate to predict phase separation, finding that small oligomers and homotypic interactions influence the threshold.

The paper demonstrates using spatial numerical simulations with Virtual Cell software to analyze FRAP experiments in complex geometries where analytic solutions are inadequate.

This study shows how the solubility product marks the threshold for condensation of multivalent biomolecules using simulations and theoretical analysis.

The paper establishes that the solubility product constant (Ksp) dictates the formation of biomolecular condensates through liquid-liquid phase separation.

The paper uses computational models to study how molecular structure and cellular organization influence clustering of multivalent molecules, revealing mechanisms that affect cluster size and phase separation potential.

This paper develops tethered bichromophoric fluorophore quencher (TBFQ) dyes for improved voltage sensing, achieving higher sensitivity and faster response kinetics than existing fluorescent voltage sensors.

The paper demonstrates the feasibility of delivering a voltage-sensitive dye to brain tissue using Regadenoson to enhance BBB permeability, as shown by increased fluorescence signal residence time.

mol2sphere transforms macromolecular structures into linked spheres for visualization and coarse-grained modeling of multi-domain proteins.

This paper extends the Virtual Cell framework to support compartmental and spatial rule-based modeling, enabling simulations of molecular interactions in defined geometries.