Author

L. N. Young

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:chromatin & epigenetic regulation· 1 Organism:human· 1 Assay:structural biology· 1

Frequent Co-Authors

J. H. Hurley· 2 shared A. L. Yokom· 1 shared C. Wang· 1 shared F. Goerdeler· 1 shared R. J. Youle· 1 shared X. Shi· 1 shared

Activity by Year

2019-2020 · peak 1/yr

Co-Author Collaboration Network

6 top collaborators · 11 mutual co-author links

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2 shared papersBiochemistry

J. H. Hurley

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2 papers

Recent·Most cited

BiochemistrybioRxivMar 19, 2020

ULK complex organization in autophagy by a C-shaped FIP200 N-terminal domain dimer

X. Shi, A. L. Yokom, C. Wang…·J. H. Hurley

The paper identifies the C-shaped dimeric structure of FIP200's N-terminal domain and its role in organizing the ULK complex by directly binding ATG13.

DOI 10.1083/jcb.201911047

humanexperimental assay

𝕏 PostBluesky

BiochemistrybioRxivSep 5, 2019

Structural Pathway for Allosteric Activation of the Autophagic PI 3-Kinase Complex I

L. N. Young, F. Goerdeler, J. H. Hurley

The paper maps structural changes in PI3KC3-C1 activation by NRBF2 MIT domains using cryo-EM, showing how binding leads to conformational shifts enabling enzymatic activity.

DOI 10.1073/pnas.1911612116

structural biologyexperimental assay

𝕏 PostBluesky