Author

R. J. Youle

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Cell Biology· 3 Biochemistry· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Organism:human· 4 Research Focus:cell signaling & trafficking· 3 Approach:experimental assay· 2 Approach:biophysical modeling· 1 Assay:CRISPR screen· 1 Approach:deep learning· 1 Research Focus:gene regulatory network inference· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

C. Wang· 2 shared A. C. Borgeaud· 1 shared A. L. Yokom· 1 shared A. Werner· 1 shared E. Dominguez-Martin· 1 shared E. N. Bunker· 1 shared F. Le Guerroue· 1 shared F. Scavone· 1 shared

Activity by Year

2018-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 13 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

2 shared papersBiochemistry

C. Wang

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Cell BiologybioRxivPreprintOct 14, 2023

STING induces HOIP-mediated synthesis of M1 ubiquitin chains to stimulate NFkB signaling

T. D. Fischer, E. N. Bunker, P.-P. Zhu…·R. J. Youle

This study shows STING activates NFkB signaling via HOIP-mediated M1 ubiquitin chains on Golgi membranes, independent of LC3B lipidation.

DOI 10.1101/2023.10.14.562349

𝕏 PostBluesky

Cell BiologybioRxivJul 2, 2020

Image-based pooled whole genome CRISPR screening for Parkin and TFEB subcellular localization

G. kanfer, S. A. Sarraf, Y. Maman…·R. J. Youle

The paper introduces AI-Photoswitchable Screening (AI-PS) to identify genes affecting subcellular localization, validating factors involved in TFEB relocation.

DOI 10.1083/jcb.202006180

humanCRISPR screen

𝕏 PostBluesky

BiochemistrybioRxivMar 19, 2020

ULK complex organization in autophagy by a C-shaped FIP200 N-terminal domain dimer

X. Shi, A. L. Yokom, C. Wang…·J. H. Hurley

The paper identifies the C-shaped dimeric structure of FIP200's N-terminal domain and its role in organizing the ULK complex by directly binding ATG13.

DOI 10.1083/jcb.201911047

humanexperimental assay

𝕏 PostBluesky

Cell BiologybioRxivAug 1, 2018

Molecular and topological reorganizations in mitochondrial architecture interplay during Bax-mediated steps of apoptosis

N. R. Ader, P. C. Hoffmann, I. Ganeva…·W. Kukulski

This study investigates how Bax activity affects mitochondrial structure during apoptosis, revealing molecular and topological changes that contribute to outer membrane rupture.

DOI 10.7554/elife.40712

𝕏 PostBluesky