Author

D. Williamson

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3 Biophysics· 2 Microbiology· 2 Cell Biology· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:statistical model· 6 Organism:human· 5 Research Focus:cell type annotation· 4 Approach:experimental assay· 4 Research Focus:gene regulatory network inference· 3 Assay:imaging· 3 Assay:bulk RNA-seq· 2 Research Focus:variant calling· 2

Frequent Co-Authors

D. Owen· 2 shared G. Taiaroa· 2 shared S. Bailey· 2 shared A. Ardaseva· 1 shared A. Cope· 1 shared A. Elder· 1 shared A. Joshi· 1 shared A. Komkov· 1 shared

Activity by Year

2018-2022 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 12 mutual co-author links

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2 shared papersBiophysics

D. Owen

Mutual co-authors in cluster

Author profile →

9 papers

Recent·Most cited

Measuring the similarity of SMLM-derived point-clouds

M. Baragilly, D. Nieves, D. Williamson, R. Peters, D. Owen

The paper introduces a tool to measure similarity between SMLM-derived point-clouds, distinguishing between conditions and identifying the source of unseen data.

bioRxiv · Sep 12, 2022 · PreprintBiophysics

Medulloblastoma Group 3 and 4 Tumors Comprise a Clinically and Biologically Significant Expression Continuum Reflecting Human Cerebellar Development

D. Williamson, E. C. Schwalbe, D. Hicks, K. A. Aldinger, J. Lindsey, S. Crosier, S. Richardson, J. Goddard, R. Hill, J. Castle, Y. Grabovska, J. Hacking, B. Pizer, S. B. Wharton, T. S. Jacques, , S. C. Clifford

The paper shows medulloblastoma Group3 and Group4 tumors form a transcriptional continuum linked to cerebellar development, with prognostic and molecular implications.

bioRxiv · Jun 9, 2022Cancer Biology

Epigenetic regulator genes direct lineage switching in MLL-AF4 leukaemia

R. Tirtakusuma, K. Szoltysek, P. Milne, V. V. Grinev, A. Ptasinska, C. Meyer, S. Nakjang, J. Y. Hehir-Kwa, D. Williamson, P. Cauchy, S. A. Assi, M. R. Imperato, F. Vogiatzi, S. Lin, M. Wunderlich, , M. J Thirman

This study shows that lineage switching in MLL-AF4 leukaemia is driven by dysregulation of epigenetic regulators like NuRD, leading to reprogramming of gene regulatory networks from B lymphoid to myeloid.

bioRxiv · Jul 16, 2021Cancer Biology

Blinking Statistics and Molecular Counting in direct Stochastic Reconstruction Microscopy (dSTORM)

L. Patel, D. Williamson, D. M. Owen, E. A. K. Cohen

The paper develops a method to accurately count molecules in dSTORM microscopy by modeling photo-switching as a Markov process and demonstrates it on T cell LAT proteins.

bioRxiv · Feb 2, 2021Biophysics

Direct RNA sequencing and early evolution of SARS-CoV-2

G. Taiaroa, D. Rawlinson, L. Featherstone, M. Pitt, L. Caly, J. Druce, D. Purcell, L. Harty, T. Tran, J. Roberts, N. Scott, M. Catton, D. Williamson, L. Coin, S. Duchene

The paper presents the first native RNA sequence of SARS-CoV-2, detailing its transcriptome and epitranscriptome, and infers genetic features and evolutionary rate.

bioRxiv · Mar 5, 2020 · PreprintMicrobiology

Differential nanoscale organisation of LFA-1 modulates T cell migration

M. Shannon, J. Pineau, J. Griffie, J. Aaron, T. Peel, D. Williamson, R. Zamoyska, A. Cope, G. Cornish, D. Owen

The paper shows that differential nanoscale organisation of LFA-1 in T-cells modulates migration speed by linking actin flow and signaling.

bioRxiv · Apr 11, 2019Immunology

Evolutionary exploitation of PD-L1 expression in hormone receptor positive breast cancer

J. West, D. Park, C. Harmon, D. Williamson, P. Ashcroft, D. Maestrini, A. Ardaseva, R. Bravo, P. Sahoo, H. Khong, K. Luddy, M. Robertson-Tessi

The paper models how timing of aromatase inhibitor and immune checkpoint inhibitor therapies affects tumor burden and metastatic potential in hormone receptor positive breast cancer.

bioRxiv · Oct 26, 2018 · PreprintCancer Biology

Appearance of synthetic vector-associated antibiotic resistance genes in next-generation sequences

G. Taiaroa, G. Cook, D. Williamson

The paper identifies synthetic vector-associated antibiotic resistance genes in public next-generation sequence datasets, which can mislead studies on antimicrobial resistance.

bioRxiv · Aug 16, 2018 · PreprintMicrobiology

Brief Freezing Steps Lead to Robust Immunofluorescence in Drosophila Larval Brains

D. Buckley, A. Thapa, M. Nguyen, E. Blankinship, D. Williamson, V. Cloud, R. D. Mohan

The paper compares immunofluorescence techniques for Drosophila larval brains, finding that freezing improves staining without compromising structural integrity.

bioRxiv · May 13, 2018Cell Biology