J. S. King

Wnt-associated adult stem cell marker Lgr6 is required for osteogenesis and fracture healing

This study shows that Lgr6 is essential for osteogenesis and fracture healing by maintaining bone volume and promoting stem cell activity in mice.

The formation and closure of macropinocytic cups in a model system

This study investigates macropinocytic cup formation and closure in Dictyostelium using lattice light-sheet microscopy, identifying two closure mechanisms and proposing a stalled wave hypothesis.

PIKfyve is required for phagosomal Rab7 acquisition and the delivery and fusion of early macropinosomes to phagosomes

This study shows that PIKfyve is essential for phagosomes to acquire Rab7 via fusion with PI(3,5)P2-positive macropinosomes, enabling efficient lysosomal component delivery.

Katnip is required to maintain microtubule function and lysosomal delivery to autophagosomes and phagosomes

The paper shows Katnip maintains microtubule function and lysosomal delivery to autophagosomes and phagosomes in Dictyostelium discoideum.

Environmental interactions with amoebae as drivers of bacterial-fungal endosymbiosis and pathogenicity

The paper identifies a bacterial endosymbiont in Rhizopus microsporus that enhances fungal virulence by suppressing amoeba predation and macrophage clearance.

Co-ordinated Ras and Rac activity shapes macropinocytic cups and enables phagocytosis of geometrically diverse bacteria

This study shows that RGBARG coordinates Ras and Rac activity to shape macropinocytic cups and enable phagocytosis of geometrically diverse bacteria in Dictyostelium discoideum.

ESCRT and autophagy cooperate to repair ESX-1-dependent damage to the Mycobacterium-containing vacuole

The paper shows that ESCRT and autophagy work together to repair damage to the Mycobacterium-containing vacuole caused by ESX-1, preventing bacterial escape.