Author

L. Scapozza

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 1 Cell Biology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 3 Approach:experimental assay· 2 Research Focus:cell type annotation· 1 Approach:comparative / phylogenetic analysis· 1 Organism:mouse· 1 Assay:proteomics· 1

Frequent Co-Authors

A. Danani· 1 shared A. Kranjc· 1 shared C. Harrison· 1 shared G. Chiriano· 1 shared G. Grasso· 1 shared H. Choi· 1 shared H. Hilbi· 1 shared H. Ouertatani Sakouhi· 1 shared

Activity by Year

2018-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 14 mutual co-author links

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1 shared paperBiophysics

A. Danani

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3 papers

Recent·Most cited

Targeted protein degradation reveals BET bromodomains as the cellular target of Hedgehog Pathway Inhibitor-1

M. Bagka, H. Choi, M. Heritier, L. Scapozza, Y. Wu, S. Hoogendoorn

This study identifies BET bromodomains as the target of HPI-1 using a PROTAC-based approach and shows HPP-9's mechanism of prolonged Hh pathway inhibition.

bioRxiv · Aug 16, 2022Cell Biology

In silico investigation of cytochrome bc1 molecular inhibition mechanism against Trypanosoma cruzi.

S. Muscat, G. Grasso, L. Scapozza, A. Danani

This study investigates the molecular mechanism of inhibitors at the Qi site of T. cruzi cytochrome bc1 using computational methods to guide drug discovery.

bioRxiv · Jun 1, 2022Biophysics

Identification of novel anti-bacterial compounds from a chemically highly diverse pathways-based library using phenotypic screens in amoebae host models

S. Kicka, N. Hanna, G. Chiriano, C. Harrison, H. Ouertatani Sakouhi, V. Trofimov, A. Kranjc, H. Hilbi, P. Cosson, L. Scapozza, T. Soldati

This study screens a diverse chemical library in amoeba models to identify anti-bacterial compounds effective against M. marinum and L. pneumophila, finding 64 active compounds with varying efficacy.

bioRxiv · Dec 17, 2018Microbiology