Cell BiologybioRxiv
Targeted protein degradation reveals BET bromodomains as the cellular target of Hedgehog Pathway Inhibitor-1
M. Bagka, H. Choi, M. Heritier…·S. Hoogendoorn
This study identifies BET bromodomains as the target of HPI-1 using a PROTAC-based approach and shows HPP-9's mechanism of prolonged Hh pathway inhibition.
DOI 10.1038/s41467-023-39657-1