N. Hanna

This study identifies LMO3 as a suppressor of the aggressive basal-like/squamous PDAC subtype, showing it reduces disease aggressiveness through modulation of glycerol 3-phosphate metabolism.

This study identifies ELAPOR1 as a tumor suppressor in pancreatic cancer, showing its association with reduced disease aggressiveness and a metabolic signature of the classical/progenitor subtype.

This study identifies SERPINB3 as a marker for the basal-like/squamous subtype of pancreatic cancer, showing it promotes invasion, metastasis, and metabolic reprogramming.

This study uses Tn-Seq to identify essential genes for Mycobacterium marinum survival in amoebae and microglial cells, revealing metabolic and virulence gene requirements during infection.

The paper shows that Drosophila's immune response to parasitoid wasps requires both danger signals from wounding and a PAMP from the wasp to trigger melanization and Tep1 expression.

The paper shows that disrupting vacuolin microdomains in Dictyostelium discoideum reduces susceptibility to Mycobacterium marinum infection by impairing membrane damage and pathogen escape.

This study identifies vacuolins in Dictyostelium discoideum as functional homologues of flotillins, essential for phagocytosis, membrane recycling, and lysosome biogenesis.

This study shows that M. marinum infection induces Zn2+ accumulation in D. discoideum phagosomes, which is counteracted by bacterial upregulation of the Zn2+ exporter CtpC.

This study screens a diverse chemical library in amoeba models to identify anti-bacterial compounds effective against M. marinum and L. pneumophila, finding 64 active compounds with varying efficacy.