Author

C. Harrison

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3 Microbiology· 3 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 7 Organism:human· 5 Research Focus:cell type annotation· 3 Research Focus:drug response / drug discovery· 3 Assay:bulk RNA-seq· 2 Research Focus:differential expression· 2 Organism:mouse· 2 Research Focus:cancer & tumor microenvironment· 1

Frequent Co-Authors

A. Hamblin· 2 shared A. J. Mead· 2 shared A. Rodriguez-Meira· 2 shared B. Psaila· 2 shared I. Antony-Debre· 2 shared M. Bashton· 2 shared M. Drummond· 2 shared S. Thongjuea· 2 shared

Activity by Year

2018-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersCancer Biology

A. Hamblin

Mutual co-authors in cluster

Author profile →

7 papers

Recent·Most cited

Chromothripsis orchestrates leukemic transformation in blast phase MPN through targetable amplification of DYRK1A

C. K. Brierley, B. H. Yip, G. Orlando, H. Goyal, S. Wen, J. Wen, M. F. Levine, M. G. Jakobsdottir, A. Rodriguez-Meira, A. Adamo, M. Bashton, A. Hamblin, S. A. Clark, J. O'Sullivan, L. Murphi, , A. J. Mead

The paper identifies chromothripsis-induced amplification of DYRK1A in blast phase MPN as a driver of aggressive disease and a potential therapeutic target.

bioRxiv · Dec 8, 2023 · PreprintCancer Biology

Deciphering TP53 mutant Cancer Evolution with Single-Cell Multi-Omics

A. Rodriguez-Meira, R. Norfo, W. X. Wen, A. L. Chedeville, H. Rahman, J. OSullivan, G. Wang, E. Louka, W. Kretzschmar, A. Paterson, C. Brierley, J.-E. Martin, C. Demeule, M. Bashton, N. Sousos, , A. J. Mead

The paper uses single-cell multi-omic analysis to study TP53-mutant cancer evolution in leukaemia, identifying a role for chronic inflammation in promoting TP53 mutant clones.

bioRxiv · Mar 28, 2022 · PreprintCancer Biology

An ex vivo human bone marrow milieu identifies CDH2 as a driver of niche-mediated treatment resistance in leukaemia

D. Pal, H. Blair, S. Boyd, S. Angel, S. Nizami, A. Isa, M. Beckett, R. Nelson, A. Wilson, M. Singh, S. Sankar, R. Tirtakusuma, S. Nakjang, C. Knill, A. Fuller, , J. Vormoor

This study identifies CDH2 as a driver of niche-mediated treatment resistance in leukemia and shows that ADH-1 can effectively target this resistance in preclinical models.

bioRxiv · Jun 18, 2021Cancer Biology

Genome sequence and characterisation of coliphage vB_Eco_SLUR29

I. Besler, P. Sazinas, C. Harrison, L. Gannon, T. Redgwell, S. Michniewski, S. Hooton, J. Hobman, A. D. Millard

The paper isolates and characterizes a new coliphage from cattle slurry, placing it in a new genus and showing lytic activity dependent on multiplicity of infection.

bioRxiv · Sep 30, 2019 · PreprintMicrobiology

Identification of novel anti-bacterial compounds from a chemically highly diverse pathways-based library using phenotypic screens in amoebae host models

S. Kicka, N. Hanna, G. Chiriano, C. Harrison, H. Ouertatani Sakouhi, V. Trofimov, A. Kranjc, H. Hilbi, P. Cosson, L. Scapozza, T. Soldati

This study screens a diverse chemical library in amoeba models to identify anti-bacterial compounds effective against M. marinum and L. pneumophila, finding 64 active compounds with varying efficacy.

bioRxiv · Dec 17, 2018Microbiology

Therapeutic blockade of Activin-A improves NK cell function and anti-tumor immunity

J. Rautela, L. F. Dagley, I. S. Schuster, S. Hediyeh-Zadeh, R. Delconte, J. Cursons, R. Hennessy, D. S. Hutchinson, C. Harrison, C. C. Oliveira, E. Vivier, A. I. Webb, M. Degli-Esposti, M. Davis, N. D. Huntington, F. Souza-Fonseca-Guimaraes

This study shows Activin-A inhibits NK cell function, promotes transdifferentiation into ILC1-like cells, and suppresses anti-tumor immunity, with therapeutic blockade improving outcomes.

bioRxiv · Oct 29, 2018 · PreprintImmunology

Viromic analysis of wastewater input to a river catchment reveals a diverse assemblage of RNA viruses

E. Adriaenssens, K. Farkas, C. Harrison, D. Jones, H. E. Allison, A. J. McCarthy

The paper uses viromics to detect RNA viruses in wastewater and river systems, identifying novel norovirus genomes and suggesting zoonotic transmission risks.

bioRxiv · Feb 21, 2018Microbiology