L. Tweedy

CYRI-B loss promotes enlarged mature focal adhesions and restricts microtubule and ERC1 access to the cell leading edge

How Should Eukaryotic Chemotaxis be Measured?

The paper identifies reliable measures of chemotactic steering and migration, highlights issues with existing metrics, and provides tools to implement these methods.

Competition between chemoattractants causes unexpected complexity and can explain negative chemotaxis

The paper shows that competition between chemoattractants can cause complex migration patterns and explain negative chemotaxis in Dictyostelium cells.

The Scar/WAVE complex drives normal actin protrusions without the Arp2/3 complex, but proline-rich domains are required

This study shows that the Scar/WAVE complex can drive normal actin protrusions without the Arp2/3 complex and that proline-rich domains are essential for actin nucleation.

Seeing around corners: Cells create chemotactic gradients to solve mazes and respond to distant cues in complex environments.

The paper shows cells use self-generated chemotactic gradients to navigate complex environments and solve mazes, with accuracy influenced by path complexity, attractant diffusibility, and cell speed.

LPP3 mediates self-generation of chemotactic LPA gradients by melanoma cells

The paper shows that LPP3 is essential for melanoma cells to break down LPA, enabling self-generated chemotaxis and invasion.