S. Zanivan

Metabolic adaptations of micrometastases alter EV production to generate invasive microenvironments

The paper shows that breast cancer micrometastases alter metabolism to change extracellular vesicle production, creating an invasive microenvironment.

CYRI-B loss promotes enlarged mature focal adhesions and restricts microtubule and ERC1 access to the cell leading edge

The helminth TGF-beta mimic TGM4 is a modular ligand that binds CD44, CD49d and TGF-beta receptors to preferentially target myeloid cells

This paper identifies TGM4, a helminth TGF-beta mimic, as a modular ligand that selectively targets myeloid cells through specific receptor interactions, differing from TGM1's broader T cell targeting.

Engineered immunomodulatory extracellular vesicles derived from epithelial cells acquire capacity for positive and negative T cell co-stimulation in cancer and autoimmunity

This study engineers extracellular vesicles from epithelial cells to express immunomodulatory proteins, showing they can induce both positive and negative T cell co-stimulation in cancer and autoimmunity.

Mitochondrial outer membrane integrity regulates a ubiquitin-dependent NF-κB inflammatory response

This study shows that mitochondrial outer membrane permeabilization triggers ubiquitin-dependent NF-κB inflammation by recruiting NEMO to ubiquitylated mitochondria.

The eIF4A2 negative regulator of mRNA translation promotes extracellular matrix deposition to accelerate hepatocellular carcinoma initiation

The paper shows that eIF4A2, a negative regulator of mRNA translation, promotes ECM deposition to accelerate HCC initiation by influencing integrin-mediated signaling and senescence exit.

Breast cancer secretes anti-ferroptotic MUFAs and depends on selenoprotein synthesis for metastasis

This study shows that triple-negative breast cancer cells secrete anti-ferroptotic MUFAs and rely on selenoprotein synthesis for metastasis.

Tumour mitochondrial DNA mutations drive aerobic glycolysis to enhance checkpoint blockade

This study shows that mitochondrial DNA mutations in complex I genes drive aerobic glycolysis, enhancing immune checkpoint blockade response in tumors.

Cancer-associated fibroblasts produce matrix-bound vesicles that influence endothelial cell function

CAFs with a myofibroblastic-like phenotype transfer proteins to ECs, including plasma membrane receptors, through matrix-bound EVs.

PTEN deficiency exposes a requirement for an ARF GTPase module in integrin-dependent invasion in ovarian cancer.

This study identifies ARF6 as a critical vulnerability in PTEN-deficient ovarian cancer, showing its role in integrin-dependent invasion and its inverse association with patient outcomes.

A palmitate-rich metastatic niche enables metastasis growth via p65 acetylation

This study identifies palmitate-rich metastatic niches as promoters of metastasis by enhancing p65 acetylation and NF-κB signaling in breast cancer cells.

MICAL1 activation by PAK1 mediates actin filament disassembly

This study identifies PAK1-mediated phosphorylation of MICAL1 as a mechanism for actin filament disassembly, linking extracellular signals to cytoskeleton regulation through RHO GTPase signaling.

Maturation, developmental site, and pathology dictate murine neutrophil function

This study identifies Ly6G expression levels as a marker for neutrophil maturation stages and shows spleen-derived neutrophils mature faster with distinct transcriptional profiles.

Ultraviolet light-induced collagen degradation inhibits melanoma invasion

This study shows UVR-induced collagen degradation by fibroblasts reduces melanoma invasion and improves survival, but melanoma-associated fibroblasts can restore invasion by increasing collagen synthesis.

Spatial enrichment of phosphoinositide metabolism is a molecular switch to promote metastasis.

This study identifies IQSEC1 variants that spatially regulate phosphoinositide metabolism to switch cell behavior from growth to invasion, with implications for metastasis.

PYCR1-dependent proline synthesis in cancer-associated fibroblasts is required for the deposition of pro-tumorigenic extracellular matrix

This study identifies PYCR1-dependent proline synthesis in cancer-associated fibroblasts as critical for collagen production and tumor progression, suggesting PYCR1 as a therapeutic target to inhibit pro-tumorigenic extracellular matrix deposition.

The Mammalian Cytosolic Thioredoxin Reductase Pathway Acts via a Membrane Protein to Reduce ER-localised Proteins

The paper demonstrates that the cytosolic thioredoxin reductase pathway reduces ER-localized proteins via a membrane protein, essential for ER redox homeostasis and protein folding.

Formate induces a metabolic switch in nucleotide and energy metabolism

This study shows formate induces a metabolic switch increasing adenine nucleotides, glycolysis, and repressing AMPK, with implications for cancer metabolism.

CYRI (FAM49) proteins are local inhibitors of Scar/WAVE induced lamellipodia that bind directly to active Rac1

This study identifies CYRI proteins as local inhibitors of Scar/WAVE-induced lamellipodia that bind to active Rac1, regulating protrusion size and complexity.