L. McGarry

The eIF4A2 negative regulator of mRNA translation promotes extracellular matrix deposition to accelerate hepatocellular carcinoma initiation

The paper shows that eIF4A2, a negative regulator of mRNA translation, promotes ECM deposition to accelerate HCC initiation by influencing integrin-mediated signaling and senescence exit.

Cancer-associated fibroblasts produce matrix-bound vesicles that influence endothelial cell function

CAFs with a myofibroblastic-like phenotype transfer proteins to ECs, including plasma membrane receptors, through matrix-bound EVs.

PTEN deficiency exposes a requirement for an ARF GTPase module in integrin-dependent invasion in ovarian cancer.

This study identifies ARF6 as a critical vulnerability in PTEN-deficient ovarian cancer, showing its role in integrin-dependent invasion and its inverse association with patient outcomes.

Ribonucleotide synthesis by NME6 fuels mitochondrial gene expression

This study shows NME6 supplies mitochondria with ribonucleotides to support mitochondrial gene transcription and DNA maintenance, with implications for cancer and autoimmune diseases.

Spatial regulation of the glycocalyx component Podocalyxin is a switch for pro-metastatic function

This study identifies PODXL as a decoy receptor for GAL3, revealing its role in promoting metastasis through integrin-based invasion and differential cortical targeting regulated by ubiquitination.

The Scar/WAVE complex drives normal actin protrusions without the Arp2/3 complex, but proline-rich domains are required

This study shows that the Scar/WAVE complex can drive normal actin protrusions without the Arp2/3 complex and that proline-rich domains are essential for actin nucleation.

The small GTPase ARF3 controls metastasis and invasion modality by regulating N-cadherin levels.

This study identifies ARF3 as a regulator of invasion modality and metastasis in prostate cancer by controlling N-cadherin levels.

Dual G9A and EZH2 inhibition stimulates an anti-tumour immune response in ovarian high-grade serous carcinoma

This study shows that dual inhibition of G9A and EZH2 in ovarian cancer enhances anti-tumour immune responses by altering the immune microenvironment and reducing tumour growth.

Spatial enrichment of phosphoinositide metabolism is a molecular switch to promote metastasis.

This study identifies IQSEC1 variants that spatially regulate phosphoinositide metabolism to switch cell behavior from growth to invasion, with implications for metastasis.

BRD4-mediated repression of p53 is a target for combination therapy in AML

This study shows that combining MDM2 inhibitors and BET inhibitors synergistically kills AML cells by enhancing p53 activation through BRD4's repressive function.