Regenerating motor neurons prime muscle stem cells for myogenesis by enhancing protein synthesis and mitochondrial bioenergetics
J. J. Choi, E. J. Shin, W. M. Han, S. E. Anderson, M. Mohiuddin, N. H. Lee, T. Tran, S. Nakhai, H. Jeong, A. Shcherbina, G. Jeong, D. G. Oh, L. Weinstock, S. B. Sankar, M. E. Ogle, , Y. C. Jang
This study shows that motor neurons enhance muscle stem cell function by boosting protein synthesis and mitochondrial activity, which is critical for muscle regeneration and is disrupted in diseases like muscular dystrophy and aging.
bioRxiv · May 24, 2020 · PreprintCell Biology