C. A. Aguilar

This study shows that manipulating Lamin A/C affects nuclear structure and reprogramming efficiency in human fibroblasts.

This study shows that Maresin 1 treatment reduces fibrosis and improves muscle regeneration after volumetric muscle loss by modulating inflammation.

This study examines how 3D chromatin organization changes in muscle stem cells during aging, revealing static global structures and rewired local contacts linked to transcription factor binding and gene expression changes.

This study identifies a pro-fibrotic immune-progenitor cell interaction in VML that impairs muscle regeneration, showing conservation across mouse and canine models.

The study compares muscle injuries leading to regeneration or fibrosis, revealing that neutrophil-natural killer cell communication affects muscle stem cell repair.

This study shows that Sestrins maintain muscle stem cell quiescence and function by regulating mTORC1 signaling and metabolism, and their loss accelerates age-related deterioration.

This study identifies age-related deficiencies in proresolving mediators in skeletal muscle, leading to impaired regeneration and inflammation, and shows that RvD1 treatment can mitigate some adverse effects.

This study shows that resolvin D1 promotes skeletal muscle regeneration by modulating myeloid cells and muscle stem cells, improving recovery without directly affecting myogenesis.

The paper identifies a neuro-responsive subset of muscle stem cells that support neuromuscular junction integrity during aging and neurodegeneration.

This study shows that motor neurons enhance muscle stem cell function by boosting protein synthesis and mitochondrial activity, which is critical for muscle regeneration and is disrupted in diseases like muscular dystrophy and aging.

This study shows that transplanting healthy muscle stem cells into dystrophic muscle improves mitochondrial function and bioenergetics, while compromised stem cells fail to do so.

This study develops pre-innervated tissue engineered muscle constructs to enhance regeneration after volumetric muscle loss in rats.